Detailed information of TA system TA170622

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 385473..386075
• Replicon: chromosome
• Accession: NZ_CP060672
• Organism: Salmonella enterica strain 190729_8

Toxin (Protein)

• Gene name: higB
• Uniprot ID: M7S4R6
• Locus tag: H9Q85_RS01835
• Protein ID: WP_001159635.1
• Coordinates: 385473..385784 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: H9Q85_RS01840
• Protein ID: WP_000362050.1
• Coordinates: 385785..386075 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9Q85_RS01800 (380586)	380586..381185	+	600	WP_000965695.1	glucose-1-phosphatase	-
H9Q85_RS01805 (381179)	381179..382051	+	873	WP_000921423.1	virulence factor BrkB family protein	-
H9Q85_RS01810 (382048)	382048..382485	+	438	WP_000560968.1	D-aminoacyl-tRNA deacylase	-
H9Q85_RS01815 (382530)	382530..383471	+	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
H9Q85_RS01820 (383486)	383486..383932	-	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
H9Q85_RS01825 (383929)	383929..384240	-	312	WP_000558168.1	type II toxin-antitoxin system HigB family toxin	-
H9Q85_RS01830 (384326)	384326..385255	-	930	WP_001127705.1	alpha/beta hydrolase	-
H9Q85_RS01835 (385473)	385473..385784	+	312	WP_001159635.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
H9Q85_RS01840 (385785)	385785..386075	+	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
H9Q85_RS01845 (386122)	386122..387051	-	930	WP_000027736.1	formate dehydrogenase accessory protein FdhE	-
H9Q85_RS01850 (387048)	387048..387683	-	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
H9Q85_RS01855 (387680)	387680..388582	-	903	WP_000331364.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12340.30 Da
• Isoelectric Point: 9.4460

>T170622 WP_001159635.1 NZ_CP060672:385473-385784 [Salmonella enterica]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T170622 NZ_CP077661:c465071-464661 [Enterobacter cloacae complex sp. ECL112]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTGGTGTTTGATAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGGGATCTGCGCCGGCTAATCGTGCAACAGCCAA
CGCAGGAATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT170622 WP_000362050.1 NZ_CP060672:385785-386075 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT170622 NZ_CP077661:c465318-465052 [Enterobacter cloacae complex sp. ECL112]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A3V2JK97