Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 383486..384240 Replicon chromosome
Accession NZ_CP060672
Organism Salmonella enterica strain 190729_8

Toxin (Protein)


Gene name higB Uniprot ID B5RFE2
Locus tag H9Q85_RS01825 Protein ID WP_000558168.1
Coordinates 383929..384240 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H9Q85_RS01820 Protein ID WP_001259009.1
Coordinates 383486..383932 (-) Length 149 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q85_RS01790 (378662) 378662..379558 + 897 WP_001520529.1 sugar kinase -
H9Q85_RS01795 (379592) 379592..380395 + 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
H9Q85_RS01800 (380586) 380586..381185 + 600 WP_000965695.1 glucose-1-phosphatase -
H9Q85_RS01805 (381179) 381179..382051 + 873 WP_000921423.1 virulence factor BrkB family protein -
H9Q85_RS01810 (382048) 382048..382485 + 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
H9Q85_RS01815 (382530) 382530..383471 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
H9Q85_RS01820 (383486) 383486..383932 - 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
H9Q85_RS01825 (383929) 383929..384240 - 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin Toxin
H9Q85_RS01830 (384326) 384326..385255 - 930 WP_001127705.1 alpha/beta hydrolase -
H9Q85_RS01835 (385473) 385473..385784 + 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system -
H9Q85_RS01840 (385785) 385785..386075 + 291 WP_000362050.1 DNA-binding transcriptional regulator -
H9Q85_RS01845 (386122) 386122..387051 - 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
H9Q85_RS01850 (387048) 387048..387683 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
H9Q85_RS01855 (387680) 387680..388582 - 903 WP_000331364.1 formate dehydrogenase subunit beta -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12324.26 Da        Isoelectric Point: 9.3143

>T170621 WP_000558168.1 NZ_CP060672:c384240-383929 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE

Download         Length: 312 bp

>T170621 NZ_CP077661:225312-225611 [Enterobacter cloacae complex sp. ECL112]
ATGATTAATCATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTCTACGGGAGATCGAGCAATGTTATTCCTTTGAATCT
GGAAACAGCGCTTGCAAGAAAGCTCGACATCATCAATGCGGCCATGTCGCACCTGGATTTACGATCGCCACCGGGCAATA
TATATGAAGCATTGAGTCCTACGTTGAAGGGATACTCCTCTATCCGGGTAAACAGACAATACAGGCTTGTATTTCGCTGG
TCAGAGGGAAAAGCAGACGATCTCTATCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT170621 WP_001259009.1 NZ_CP060672:c383932-383486 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT170621 NZ_CP077661:225622-225969 [Enterobacter cloacae complex sp. ECL112]
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGAGGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAACGATCTGGCAGAGGTGCTAAATGTACACCGCAATACCGTAAGCGCGTTGGTCAATAACAATCGCAAACTTA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTAATACCACTATTGAATTTTGGCTGAACTTACAGCTAAACGTTGAT
ATCTGGGAAACGCAATCTAACTCCCGCACGCAGGAGGAGTTAAGCCGGATAAAAACCGTTGCGGAAGTCATGGCGAAGCG
AAAATCCGGCAAGCCGGACGTTGCCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1R2S541


Antitoxin

Source ID Structure

References