Detailed information of TA system TA170541

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2085070..2085295
• Replicon: chromosome
• Accession: NZ_CP060666
• Organism: Salmonella enterica strain 190821_1

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: H9Q88_RS10270
• Protein ID: WP_000813254.1
• Coordinates: 2085070..2085225 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2085237..2085295 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9Q88_RS10235	2080177..2080458	-	282	WP_000445513.1	phage holin family protein	-
H9Q88_RS10240	2080448..2080636	-	189	WP_001688615.1	putative holin	-
H9Q88_RS10245	2080630..2080953	-	324	Protein_2003	tellurite/colicin resistance protein	-
H9Q88_RS10250	2083124..2083660	-	537	WP_000640113.1	DUF1133 family protein	-
H9Q88_RS10255	2083657..2083947	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
H9Q88_RS10260	2083947..2084546	-	600	WP_000940751.1	DUF1367 family protein	-
H9Q88_RS10265	2084609..2084779	-	171	WP_000734094.1	hypothetical protein	-
H9Q88_RS10270	2085070..2085225	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2085237..2085295	+	59	-	-	Antitoxin
H9Q88_RS10275	2085652..2086584	+	933	WP_000556390.1	hypothetical protein	-
H9Q88_RS10280	2086581..2087135	+	555	WP_001033796.1	hypothetical protein	-
H9Q88_RS10285	2087297..2087626	-	330	WP_001676916.1	DUF977 family protein	-
H9Q88_RS10290	2087670..2087717	-	48	Protein_2012	hypothetical protein	-
H9Q88_RS10295	2087899..2088366	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
H9Q88_RS10300	2088751..2088906	+	156	WP_085981757.1	DUF1391 family protein	-
H9Q88_RS10305	2089014..2089535	-	522	WP_000004762.1	super-infection exclusion protein B	-
H9Q88_RS10310	2089973..2090194	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2079635..2091506	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T170541 WP_000813254.1 NZ_CP060666:c2085225-2085070 [Salmonella enterica]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T170541 NZ_CP077425:1031609-1031878 [Vibrio mimicus]
ATGCCAGAGATTGATGCCCTATTAGGCCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTGCCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT170541 NZ_CP060666:2085237-2085295 [Salmonella enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin