Detailed information of TA system TA170518

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 59657..60350
• Replicon: plasmid pUnnamed1
• Accession: NZ_CP060593
• Organism: Rouxiella badensis strain C173

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: H2866_RS22790
• Protein ID: WP_192504575.1
• Coordinates: 60054..60350 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: H2866_RS22785
• Protein ID: WP_192504574.1
• Coordinates: 59657..60052 (-)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H2866_RS22760	54908..56869	-	1962	WP_192504570.1	relaxase/mobilization nuclease domain-containing protein	-
H2866_RS22765	56869..57180	-	312	WP_017493764.1	mobilization protein	-
H2866_RS22770	57450..57782	+	333	WP_192504571.1	hypothetical protein	-
H2866_RS22775	57921..58742	-	822	WP_192504572.1	DUF945 domain-containing protein	-
H2866_RS22780	58797..59162	-	366	WP_192504573.1	hypothetical protein	-
H2866_RS22785	59657..60052	-	396	WP_192504574.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
H2866_RS22790	60054..60350	-	297	WP_192504575.1	type II toxin-antitoxin system MqsR family toxin	Toxin
H2866_RS22795	60477..60917	-	441	WP_192504490.1	antirestriction protein	-
H2866_RS22800	61044..61358	-	315	WP_192504491.1	hypothetical protein	-
H2866_RS22805	61428..61610	-	183	WP_192504492.1	cobalamin biosynthesis protein CbiX	-
H2866_RS22810	61858..62001	-	144	WP_192504493.1	hypothetical protein	-
H2866_RS22815	61994..62506	-	513	WP_192504494.1	antirestriction protein	-
H2866_RS22820	62996..63322	-	327	WP_192504495.1	hypothetical protein	-
H2866_RS22825	63319..63822	-	504	WP_192504496.1	hypothetical protein	-
H2866_RS22830	64270..64506	-	237	WP_192504497.1	hypothetical protein	-
H2866_RS22835	64535..64966	-	432	WP_192504498.1	hypothetical protein	-
H2866_RS22840	65018..65161	-	144	WP_192504499.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..120691	120691

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Zinc finger, MqsA-type (3-45)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10897.68 Da
• Isoelectric Point: 8.5012

>T170518 WP_192504575.1 NZ_CP060593:c60350-60054 [Rouxiella badensis]
MEKKTPHTRLHLVQALVAEGKVRATNTAMNGADELGLTFDGMCDAIKGLKMSDFFKSMTTYNDHTVWQDVYRPTLACGVV
YLKLTVSNGVLIVSFKEK

Nucleotide

• Length: 297 bp

>T170518 NZ_CP077421:4999652-5000971 [Pectobacterium polaris]
ATGGCTGCGCTCGATGTTTACATGAACGGCTATCGGGTGGGGATTCTGACCAAAACGGGCAGTGGGGCACATCATTTTTC
CTATGATGCGAACTGGCTCGGATTGCCGGGGAGTCGCCCCATTTCGCTTTCTATGCCGCTACGTCATCAGCCCTATCAAG
GTGATGAAGTTTATAACTTCTTCGACAATTTGTTGCCGGATAACCCGGATATCAGAAGACGGATTGTCGCCAGGCATCGC
GCGGATTCCACCCAACCGTTTGATCTGCTGGCTAAAGTGGGGCAAGACAGTGTCGGGGCGTTGCAATTAGTGCCGCAGGG
TACACCTGTGCATGATATAAAAAAGATCGAATACAAAACCTTATCCGAGCAGCAGCTTGAAAACATACTGACCGGATATC
TGTCCGATGCCCCGCTGGGGATGATTGATACTGAAGACGATTTTCGTATTTCTATCGCAGGTGCACAGGAAAAGACGGCG
CTACTTTATCTGGATGATCACTGGCGCCTGCCTCTCAATGCCACACCAACTACCCACATCATCAAGCTACCGATTGGTAA
AATCGAGAGTCACTCTTACTCAATTGATATGTCTGACAGCGTTGAAAATGAGTATCTGTGTTTGCTCATTGCCAAGGCAT
TTGGGCTGCCAGTGCCGCGCTGTTTTATGATCAACGCTGGCAAGATAAAGGCGTTGGCGGTGGAGCGTTTTGATCGTAAA
TACGCCTCGGATGTCAGTTGGATTATGCGGCTACCACAAGAGGATTTTTGTCAGGTATTAAACGTTCCTTCCGCACTGAA
ATATGAAAATCATGGTGGACCGGGTATTTCCGCCATTATGTCGTTTCTATTGGGTTCGGTTGATCCAGAAAGAGATCGTT
ATCGCTTTATGCAGGCTCAGGTACTGTTTTGGCTATTGGCTGCAACGGATGGTCATGCGAAAAACTTTTCCCTGTTTATT
GAATCTGAGGGGCGATATCGACTCACGCCTTTCTATGACATTCTCTCCATGTATCCAGCGATGGGCGGACGGGGAATTGA
CCGCAGAGAAGCCAAACTGGCGATGGGATTGACTGGCTCAAGAGGCAAGAAATATGCGACTGAGCAGATCTTTCCCCGAC
ATTTTTTCCAGACGGCGAAGGCTGTTGGGTTTGCCAGAGAATCGATGGAAAACATTCTGGTGGAGTTTGCCCACGCCATT
GATACCGTCATGACGACTGTTGGAAGTCAACTGCCTGTGGATTTTCCTACTCATATCAGTGAGGCAATTCTGGCCGGGTT
GCAGGCCAGATCGAGACGGCTCATGAGCGGATGGGAGTAA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14367.53 Da
• Isoelectric Point: 8.5023

>AT170518 WP_192504574.1 NZ_CP060593:c60052-59657 [Rouxiella badensis]
MKCSVCGGAELAFGTKKVPYSFRGHKTQIDAEGEHCPACGEVNMDRDQANAYQAKLKAFKAQIIAVTVEPEFIVSVRKKL
ALTQKEASEIFGGGVNAFSRYEKGVAQPHPSTIKLLRVLDHHPELLNEIRG

Nucleotide

• Length: 396 bp

>AT170518 NZ_CP077421:4999386-4999652 [Pectobacterium polaris]
ATGAAAGTCACCAACAGCAAGCAGCTTAGTAGCTATCTGAAAGATGTCCGTATCACGCAGAAGCTTTCACAAGGGAAAGT
GGCCAGTAAAGTGGGTATTCGCCAGGATACGGTATCCAGTTTCGAGCAACATCCTGATTCCACTAAGCTGGAAACCTTCT
TTAAAATCCTGTCGGCATTGAATTTAGAACTTACTGTTACGCCCAGAAATGTGGACACCACCAATAACGAAGCCTCTGTT
GCATCATCCTGGAAGGAAGAGTGGTAA