Detailed information of TA system TA170501

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1006553..1006735
• Replicon: chromosome
• Accession: NZ_CP060584
• Organism: Staphylococcus aureus strain WH52

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: H9M95_RS05050
• Protein ID: WP_001801861.1
• Coordinates: 1006640..1006735 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1006553..1006612 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9M95_RS05035	1005691..1006068	+	378	WP_001037045.1	DUF1433 domain-containing protein	-
H9M95_RS05040	1006262..1006438	+	177	Protein_952	transposase	-
H9M95_RS05045	1006416..1006517	-	102	WP_001791893.1	hypothetical protein	-
-	1006553..1006612	+	60	-	-	Antitoxin
H9M95_RS05050	1006640..1006735	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
H9M95_RS05055	1006938..1007081	+	144	WP_001549059.1	transposase	-
H9M95_RS05060	1007685..1008068	+	384	WP_000070811.1	hypothetical protein	-
H9M95_RS05065	1008079..1008255	+	177	WP_000375476.1	hypothetical protein	-
H9M95_RS05070	1008257..1008442	+	186	WP_000809857.1	hypothetical protein	-
H9M95_RS05075	1008556..1009197	+	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
H9M95_RS05080	1009415..1009966	-	552	WP_000414205.1	hypothetical protein	-
H9M95_RS05085	1010064..1010408	-	345	WP_000627551.1	DUF3969 family protein	-
H9M95_RS05090	1010449..1011075	-	627	WP_000669046.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlgA / lukD	973463..1044174	70711

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T170501 WP_001801861.1 NZ_CP060584:c1006735-1006640 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T170501 NZ_CP077412:c7136-6849 [Enterobacter asburiae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Nucleotide

• Length: 60 bp

>AT170501 NZ_CP060584:1006553-1006612 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin