Detailed information of TA system TA170493

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 699662..699925
• Replicon: chromosome
• Accession: NZ_CP060584
• Organism: Staphylococcus aureus strain WH52

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: H9M95_RS03330
• Protein ID: WP_001802298.1
• Coordinates: 699662..699766 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	699761..699925 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9M95_RS03305	695046..695828	+	783	WP_000908177.1	ABC transporter ATP-binding protein	-
H9M95_RS03310	695896..696753	+	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
H9M95_RS03315	697458..697550	-	93	WP_001790138.1	hypothetical protein	-
H9M95_RS03320	697839..698975	+	1137	WP_000115562.1	SAP domain-containing protein	-
H9M95_RS03325	699018..699501	+	484	Protein_653	recombinase family protein	-
H9M95_RS03330	699662..699766	+	105	WP_001802298.1	hypothetical protein	Toxin
-	699761..699925	-	165	-	-	Antitoxin
H9M95_RS03335	700266..701357	-	1092	WP_000495671.1	lytic regulatory protein	-
H9M95_RS03340	701623..702603	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
H9M95_RS03345	702605..702925	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
H9M95_RS03350	703077..703742	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T170493 WP_001802298.1 NZ_CP060584:699662-699766 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T170493 NZ_CP077411:1054178-1054699 [Enterobacter asburiae]
GTGGAGAATCTCACGATCGAAATGTTATCAGAGGGAACCGATTATGACTTCGAGTATTTTGATTGTGGCGAACCCTCGCT
AAATGCCTTCCTTGCTGAACATCTGGTGCGTCAGCACAATGGGCGTATTTTACGAGCCTACCTGCTTAAAGAGCGCGATC
GTCCGCGTGTCCTGGGTTATTACACGTTATCGGGAAGCTGTTTTGAAAGAGCGATGCTTCCTTCTAAGACTCAGCAGCGC
CGAATCCCTTATATCAACGTACCCAGCGTGACGCTGGGACGTCTGGCTGTAGATAAAACACTACAGGGAAACGAGTGGGG
AACAACGCTCGTTGCGCATGCTATGCGCGTTGTCTACCTGGCTTCACAGGCTGTGGGGGTACACGGATTATTTGTTGATG
CCCTTAACGAGCGGGCAAAACGATTTTATCTGAAGCAGGGCTTTATCCCGCTGACAGCTGAAAACAGCCATTCTTTGTTC
TTCCCTACAAAATCTATCGAACGGCTGTTTGAGCAAGAGTGA

Antitoxin

Nucleotide

• Length: 165 bp

>AT170493 NZ_CP060584:c699925-699761 [Staphylococcus aureus]
GTAGCAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin