Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 432485..433002 Replicon chromosome
Accession NZ_CP060584
Organism Staphylococcus aureus strain WH52

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag H9M95_RS01940 Protein ID WP_000113262.1
Coordinates 432736..433002 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag H9M95_RS01935 Protein ID WP_000584499.1
Coordinates 432485..432736 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9M95_RS01905 428182..428901 + 720 WP_000479576.1 amino acid ABC transporter permease -
H9M95_RS01910 428898..429629 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
H9M95_RS01915 429760..430977 - 1218 WP_048665230.1 FemA/FemB family glycyltransferase FmhA -
H9M95_RS01920 431232..431594 + 363 WP_000819843.1 DUF4467 domain-containing protein -
H9M95_RS01925 431613..432212 + 600 WP_000162813.1 DsbA family protein -
H9M95_RS01930 432219..432320 + 102 WP_001791744.1 hypothetical protein -
H9M95_RS01935 432485..432736 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
H9M95_RS01940 432736..433002 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
H9M95_RS01945 433037..433108 + 72 Protein_386 hypothetical protein -
H9M95_RS01950 433297..434844 + 1548 WP_001551849.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
H9M95_RS01955 435030..435497 + 468 WP_000153344.1 SRPBCC domain-containing protein -
H9M95_RS01960 435581..435763 + 183 WP_000230294.1 hypothetical protein -
H9M95_RS01965 435980..436804 + 825 WP_000572040.1 formate/nitrite transporter family protein -
H9M95_RS01970 437037..437573 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T170492 WP_000113262.1 NZ_CP060584:432736-433002 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T170492 NZ_CP077411:c401127-400909 [Enterobacter asburiae]
ATGTCTGATAAACCACTCACAAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACGCTTGAGCGCGT
CATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAAC
TGACAATGAATAAACTGTATGACAAAATCCCTACTTCTGTGTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT170492 WP_000584499.1 NZ_CP060584:432485-432736 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT170492 NZ_CP077411:c401529-401155 [Enterobacter asburiae]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGTTACGGCATTAACGCTCAGGATTTGCAAAAATGGCGTAAATCGGGAAATCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTGAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References