Detailed information of TA system TA170474

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 13397..14054
• Replicon: plasmid pS7697-1
• Accession: NZ_CP060509
• Organism: Salmonella enterica strain SLR1_7697

Toxin (Protein)

• Gene name: higB
• Uniprot ID: U3PDC3
• Locus tag: H9L34_RS22540
• Protein ID: WP_000270043.1
• Coordinates: 13704..14054 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: H9L34_RS22535
• Protein ID: WP_000124640.1
• Coordinates: 13397..13699 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9L34_RS22490	9020..9448	+	429	WP_000591074.1	hypothetical protein	-
H9L34_RS22495	9505..9864	+	360	WP_000422768.1	hypothetical protein	-
H9L34_RS22500	9864..10310	+	447	WP_000919345.1	Fe3+-siderophore ABC transporter permease	-
H9L34_RS22505	10307..10825	+	519	WP_020833600.1	hypothetical protein	-
H9L34_RS22510	10825..11055	+	231	WP_020833601.1	hypothetical protein	-
H9L34_RS22515	11042..11899	+	858	WP_052870225.1	hypothetical protein	-
H9L34_RS22520	12130..12657	+	528	WP_020833604.1	thermonuclease family protein	-
H9L34_RS22525	12715..12987	+	273	WP_020833605.1	HU family DNA-binding protein	-
H9L34_RS22530	13076..13369	+	294	WP_020833606.1	chromosome segregation protein ParM	-
H9L34_RS22535	13397..13699	-	303	WP_000124640.1	XRE family transcriptional regulator	Antitoxin
H9L34_RS22540	13704..14054	-	351	WP_000270043.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H9L34_RS22545	14217..14765	+	549	WP_001061574.1	transcriptional regulator	-
H9L34_RS22550	15106..15300	+	195	WP_000343597.1	hypothetical protein	-
H9L34_RS22555	15308..15679	+	372	WP_020833608.1	hypothetical protein	-
H9L34_RS22560	15672..16142	+	471	WP_001281821.1	hypothetical protein	-
H9L34_RS22565	16151..16507	-	357	WP_020833609.1	hypothetical protein	-
H9L34_RS22570	16604..17092	+	489	WP_001273096.1	DUF1643 domain-containing protein	-
H9L34_RS22575	17095..17592	+	498	WP_000062185.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..209422	209422

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 17237.68 Da
• Isoelectric Point: 5.5500

>T170474 WP_000270043.1 NZ_CP060509:c14054-13704 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 351 bp

>T170474 NZ_CP077405:c2599949-2599846 [Citrobacter braakii]
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 14882.85 Da
• Isoelectric Point: 5.5500

>AT170474 WP_000124640.1 NZ_CP060509:c13699-13397 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 303 bp

>AT170474 NZ_CP077405:2599841-2599984 [Citrobacter braakii]
CACATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGT

Structures

Toxin

• AlphaFold DB: A0A7G8AFB9