Detailed information of TA system TA170467

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1042723..1042905
• Replicon: chromosome
• Accession: NZ_CP060491
• Organism: Staphylococcus aureus strain WH39

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: H8N04_RS05415
• Protein ID: WP_001801861.1
• Coordinates: 1042810..1042905 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1042723..1042782 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H8N04_RS05375	1037723..1037917	-	195	Protein_1019	IS3 family transposase	-
H8N04_RS05380	1038186..1039181	-	996	WP_053017818.1	putative sulfate exporter family transporter	-
H8N04_RS05385	1039296..1040117	+	822	WP_000371597.1	LysR family transcriptional regulator	-
H8N04_RS05390	1040255..1040959	+	705	WP_048665789.1	helix-turn-helix domain-containing protein	-
H8N04_RS05395	1040878..1041807	+	930	WP_117206203.1	IS3 family transposase	-
H8N04_RS05400	1042035..1042238	+	204	Protein_1024	DUF1433 domain-containing protein	-
H8N04_RS05405	1042432..1042608	+	177	Protein_1025	transposase	-
H8N04_RS05410	1042586..1042687	-	102	WP_001791893.1	hypothetical protein	-
-	1042723..1042782	+	60	-	-	Antitoxin
H8N04_RS05415	1042810..1042905	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
H8N04_RS05420	1043108..1043251	+	144	WP_001549059.1	transposase	-
H8N04_RS05425	1043855..1044238	+	384	WP_000070812.1	hypothetical protein	-
H8N04_RS05430	1044249..1044425	+	177	WP_000375476.1	hypothetical protein	-
H8N04_RS05435	1044427..1044612	+	186	WP_000809857.1	hypothetical protein	-
H8N04_RS05440	1044726..1045367	+	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
H8N04_RS05445	1045585..1046136	-	552	WP_000414205.1	hypothetical protein	-
H8N04_RS05450	1046234..1046578	-	345	WP_000627551.1	DUF3969 family protein	-
H8N04_RS05455	1046619..1047245	-	627	WP_000669046.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	fusB	-	1008781..1068931	60150

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T170467 WP_001801861.1 NZ_CP060491:c1042905-1042810 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T170467 NZ_CP077404:511929-512120 [Streptococcus mutans]
TTGCCATTAACAGGGAAAGAATTAGCTAGATTAGCGATAAACAATGGATGGGAAGAAGTTCGGGTGAGAGGAAGTCATCA
TCATTTCAAGAAAGATGGAGTACCTTATATTGTGACGATTCCCATTCATGGAAATAAAGTGCTTAAAATTGGTCTTGAAA
AGAAACTCTTAAGGGATTTAAATTTATTATGA

Antitoxin

Nucleotide

• Length: 60 bp

>AT170467 NZ_CP060491:1042723-1042782 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin