170458

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 465860..466377 Replicon chromosome
Accession NZ_CP060491
Organism Staphylococcus aureus strain WH39

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag H8N04_RS02235 Protein ID WP_000113262.1
Coordinates 466111..466377 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag H8N04_RS02230 Protein ID WP_000584499.1
Coordinates 465860..466111 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8N04_RS02195 461326..461538 + 213 Protein_436 cystatin-like fold lipoprotein -
H8N04_RS02200 461588..462262 - 675 WP_031919200.1 IS6-like element IS257 family transposase -
H8N04_RS02205 463030..463587 + 558 WP_048665604.1 hypothetical protein -
H8N04_RS02210 464071..464745 - 675 WP_001105987.1 IS6-like element IS257 family transposase -
H8N04_RS02215 464793..464969 + 177 Protein_440 cystatin-like fold lipoprotein -
H8N04_RS02220 464988..465587 + 600 WP_000162813.1 DsbA family protein -
H8N04_RS02225 465594..465695 + 102 WP_001791744.1 hypothetical protein -
H8N04_RS02230 465860..466111 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
H8N04_RS02235 466111..466377 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
H8N04_RS02240 466412..466483 + 72 Protein_445 hypothetical protein -
H8N04_RS02245 466672..468222 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
H8N04_RS02250 468408..468875 + 468 WP_000153344.1 SRPBCC domain-containing protein -
H8N04_RS02255 468959..469141 + 183 WP_000230294.1 hypothetical protein -
H8N04_RS02260 469358..470182 + 825 WP_000572040.1 formate/nitrite transporter family protein -
H8N04_RS02265 470415..470951 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T170458 WP_000113262.1 NZ_CP060491:466111-466377 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T170458 NZ_CP077392:c3717411-3717124 [Enterobacter hormaechei]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT170458 WP_000584499.1 NZ_CP060491:465860-466111 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT170458 NZ_CP077392:c3717650-3717411 [Enterobacter hormaechei]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References