Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4891876..4892606 Replicon chromosome
Accession NZ_CP060440
Organism Serratia marcescens strain M158-1-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H3V66_RS23555 Protein ID WP_126180458.1
Coordinates 4892295..4892606 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A5C7DE62
Locus tag H3V66_RS23550 Protein ID WP_049198530.1
Coordinates 4891876..4892298 (-) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3V66_RS23535 4887736..4888476 + 741 WP_123892724.1 KDGP aldolase family protein -
H3V66_RS23540 4888688..4889902 + 1215 WP_084827496.1 lactonase family protein -
H3V66_RS23545 4889954..4891870 + 1917 WP_174137245.1 PRD domain-containing protein -
H3V66_RS23550 4891876..4892298 - 423 WP_049198530.1 helix-turn-helix domain-containing protein Antitoxin
H3V66_RS23555 4892295..4892606 - 312 WP_126180458.1 type II toxin-antitoxin system HigB family toxin Toxin
H3V66_RS23560 4892903..4893175 - 273 WP_004937034.1 PTS phosphocarrier protein NPr -
H3V66_RS23565 4893172..4894026 - 855 WP_015379177.1 RNase adapter RapZ -
H3V66_RS23570 4894156..4894617 - 462 WP_016930212.1 PTS IIA-like nitrogen regulatory protein PtsN -
H3V66_RS23575 4894773..4895060 - 288 WP_004937038.1 ribosome hibernation promoting factor -
H3V66_RS23580 4895084..4896517 - 1434 WP_049198529.1 RNA polymerase factor sigma-54 -
H3V66_RS23585 4896570..4897295 - 726 WP_049198528.1 LPS export ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(81-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12262.11 Da        Isoelectric Point: 10.0957

>T170397 WP_126180458.1 NZ_CP060440:c4892606-4892295 [Serratia marcescens]
MHIISREPFNNATKQYPNEAAALEAIYKTLRRGEFRTPDELKALFPSLDRMKYKEKWWVIDVGGSHLRILFFASFETQKV
FIKHIVSHAEYDKLMQHYRRSSS

Download         Length: 312 bp

>T170397 NZ_CP077331:623848-623938 [Lelliottia amnigena]
AGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTATCCCAAGAGCCATTTCCCTGGACCGAATACAGGAATCGTATTC
GGTCTCTTTTT

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15643.94 Da        Isoelectric Point: 4.9590

>AT170397 WP_049198530.1 NZ_CP060440:c4892298-4891876 [Serratia marcescens]
MITDAIKAADALLRAVPLLQGSGSQQDYREALELVEYLLENDEHHPLIDMLAKKIAEYEDNGAEFTAFNQRIAQLPQGVA
ALRVLMEQHQLSQSDFEHEIGKKSLVNQILSGKRSLTIPHIMALAKRFNLPPALFLPEAD

Download         Length: 423 bp

>AT170397 NZ_CP077331:c623943-623769 [Lelliottia amnigena]
CAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGATAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAACTACGCCTGACACTCTAAGAATAGATGACGACGCCAGGTTTTCCAGTCCGCGACTAAAGTGG
TCAGAAAAAAAGCGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5C7DE62

References