Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 225110..225690 Replicon chromosome
Accession NZ_CP060436
Organism Pseudooceanicola algae strain Lw-13e

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PSAL_RS01060 Protein ID WP_119838420.1
Coordinates 225110..225391 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag PSAL_RS01065 Protein ID WP_119838421.1
Coordinates 225403..225690 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSAL_RS01035 223529..223660 + 132 WP_119840379.1 transposase -
PSAL_RS01040 223861..224070 - 210 Protein_202 IS3 family transposase -
PSAL_RS01045 224125..224415 + 291 WP_196941888.1 hypothetical protein -
PSAL_RS01050 224419..224631 + 213 WP_119838418.1 hypothetical protein -
PSAL_RS01055 224724..225017 + 294 WP_196222738.1 transposase -
PSAL_RS01060 225110..225391 + 282 WP_119838420.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PSAL_RS01065 225403..225690 + 288 WP_119838421.1 HigA family addiction module antidote protein Antitoxin
PSAL_RS01070 225830..228730 - 2901 WP_119838430.1 type I restriction endonuclease subunit R -
PSAL_RS01075 229228..230304 + 1077 WP_119838422.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 223861..224109 248


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(29-69)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10405.05 Da        Isoelectric Point: 10.2613

>T170374 WP_119838420.1 NZ_CP060436:225110-225391 [Pseudooceanicola algae]
MIQSAKGKLATNALQGKYGKRFPTDLVKRTRAMLTALDAAVVVEDLRFPPGNKLEELKGDRAGQHSVRINGQWRICFVWT
PKGPAEVEIVDYH

Download         Length: 282 bp

>T170374 NZ_CP077304:72534-72863 [Acinetobacter pittii]
ATGTATACAATTGAATATTACAGCGAAGACGTTCAGGATGAGATTCTTACATTACCTGATGGTCTTTTGGCTCGATATTT
TAACTTAACTGACCGTATGGTGATTTACGGCGCAAACTTAGGAGAACCTCACACATTACCAATGAGTAAAGGACTATTTG
AGTTGCGCTTAAAATCTCAAGAAGGTATTGCTCGTGTTATGTATTGCACACTAGTCGGTAAACGCATTGTAATGCTCCAT
AGTTTTGTTAAGAAAACCCAAAAAACACCTAAGCAAGATCTAAACCTAGCACTTGACCGCATGAAAGAGGTGAAAAATGC
GAACACATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10658.34 Da        Isoelectric Point: 4.7440

>AT170374 WP_119838421.1 NZ_CP060436:225403-225690 [Pseudooceanicola algae]
MSLLEDPMHPGEVLKELYLDPLDIGAIGLARRLGVPRTRIERLVKGATSMTPDTALRLAHVFNTTPEYWMNMQTNFDMHA
AIQQIDVSDIEPLVA

Download         Length: 288 bp

>AT170374 NZ_CP077304:72850-73137 [Acinetobacter pittii]
ATGCGAACACATGAAGAAATGAAAGCACTTGCATTATCTCGTTCAGCAGTGCGTACCGAATACGAACGAATTGAACGTGA
AGAAATGCCCCTGCTCGATATGGTACTTACTGCACGTCGAGATGCAGGTCTATCCCAAGCGCAAATCGCGGAACGCATGG
GAACAAGTGTACCTGCCGTTTCACGGCTAGAAAAAGCATTGATCACAGGCAAACCATCACCATCTATTGCCACATTGCAA
AAATATGCTGCGGCAATTGGTAAACATGTTGAAGTGCGTTTTGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References