170366

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3970682..3971279 Replicon chromosome
Accession NZ_CP060421
Organism Klebsiella pneumoniae strain BA2105

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag HBJ34_RS19975 Protein ID WP_004142563.1
Coordinates 3970962..3971279 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag HBJ34_RS19970 Protein ID WP_004142561.1
Coordinates 3970682..3970969 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBJ34_RS19940 3966763..3967011 + 249 WP_002893037.1 DUF1158 domain-containing protein -
HBJ34_RS19945 3967029..3967370 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
HBJ34_RS19950 3967401..3968516 - 1116 WP_166702185.1 MBL fold metallo-hydrolase -
HBJ34_RS19955 3968695..3969276 + 582 WP_166702183.1 TetR/AcrR family transcriptional regulator -
HBJ34_RS19960 3969276..3969644 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
HBJ34_RS19965 3969764..3970417 + 654 Protein_3915 oxygen-insensitive NAD(P)H nitroreductase -
HBJ34_RS19970 3970682..3970969 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
HBJ34_RS19975 3970962..3971279 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HBJ34_RS19980 3971464..3972507 - 1044 WP_032419264.1 DUF2157 domain-containing protein -
HBJ34_RS19985 3973174..3974040 - 867 WP_032419265.1 helix-turn-helix transcriptional regulator -
HBJ34_RS19990 3974149..3975576 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T170366 WP_004142563.1 NZ_CP060421:c3971279-3970962 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T170366 NZ_CP077302:c1304535-1304227 [Corynebacterium coyleae]
GTGGAGATCATTTCCAGCAGCTTGTTTGACGCCTGGTTAGGTGAGCTAAAAGACAAACATGCTCAGCGACGCATTTTGTA
TGCAATAGCCCGATGCGAAGCACACGGAAGAATGATTGGAGACATCAAACCCGTTGGCGAGAAGGTTAGCGAGATGAGAT
TTCATTTCGGGCCCGGCTATCGGGTGTACTACACCCGACTAGGCGCAATAACGGTTTTCCTGCTGGCCGGAGGAGATAAA
TCCAGCCAGGATAAAGATATTCGAACAGCTCAAAAGCTCGCACAACAGGTAAGGGAGGAACAGTCGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT170366 WP_004142561.1 NZ_CP060421:c3970969-3970682 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT170366 NZ_CP077302:c1304230-1303937 [Corynebacterium coyleae]
GTGAAGGAAGTAACATTTTCAGCGTTCGATGCAAGCAAATATCTCGATAGCCAAGAAGCAGTGAACGATTACCTGGCTAT
CGCACTCGAAGACGGCGATACGAAAACCGTTCAGGTGGTTTTGCGTGACATTGCAAGGGCACACGGCATGAGCCAGCTCG
CTAAAGAGACTCAACTCAACCGTGAATCCCTCTACAAGTCACTATCAAAAGACGGTAACCCGTCCTTTGCGGCTATCACG
AAAATCATGAAAGCCCTGGGACTCAAAATAACTCTCGCTACACAAAATGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References