Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 3325130..3325780 Replicon chromosome
Accession NZ_CP060401
Organism Xenorhabdus nematophila strain SII

Toxin (Protein)


Gene name higB Uniprot ID N1NNR7
Locus tag H8F46_RS14810 Protein ID WP_010847562.1
Coordinates 3325472..3325780 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H8F46_RS14805 Protein ID WP_010847563.1
Coordinates 3325130..3325426 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F46_RS14775 3320550..3321242 - 693 WP_013183086.1 envelope stress response regulator transcription factor CpxR -
H8F46_RS14780 3321395..3321895 + 501 WP_010847568.1 Spy/CpxP family protein refolding chaperone -
H8F46_RS14785 3322268..3322711 + 444 WP_010847567.1 hypothetical protein -
H8F46_RS14790 3322843..3323016 + 174 WP_038220160.1 type II toxin-antitoxin system HicA family toxin -
H8F46_RS14795 3323071..3323487 + 417 WP_010847564.1 type II toxin-antitoxin system HicB family antitoxin -
H8F46_RS14800 3323595..3324843 + 1249 Protein_2877 IS3 family transposase -
H8F46_RS14805 3325130..3325426 - 297 WP_010847563.1 helix-turn-helix domain-containing protein Antitoxin
H8F46_RS14810 3325472..3325780 - 309 WP_010847562.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H8F46_RS14815 3326126..3327025 + 900 WP_010847560.1 CDF family cation-efflux transporter FieF -
H8F46_RS14820 3327259..3328236 + 978 WP_013183083.1 6-phosphofructokinase -
H8F46_RS14825 3328539..3329525 + 987 WP_113935453.1 sulfate ABC transporter substrate-binding protein -
H8F46_RS14830 3329661..3330767 - 1107 WP_038219933.1 Fic family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-92)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11887.92 Da        Isoelectric Point: 10.5016

>T170333 WP_010847562.1 NZ_CP060401:c3325780-3325472 [Xenorhabdus nematophila]
VYKRQVFSRERAELLTDDEFRHLQEHLLKNHEQGSTISATGGCKKIRLQREGMGKRGGVRIIYYTIIKTGMLYLLLIYPK
NKKDDLTPKQKEVLKAISNKLQ

Download         Length: 309 bp

>T170333 NZ_CP077290:4704715-4704817 [Enterobacter cancerogenus]
GCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11083.80 Da        Isoelectric Point: 7.3210

>AT170333 WP_010847563.1 NZ_CP060401:c3325426-3325130 [Xenorhabdus nematophila]
MDKKLFDDLIESMNQMVAIDKGELSVPAENIHRHRLPDVKKLRETFGLKQSEFAEAVGVSASLIQSWEQHRRTPSGSSLK
LLKMLERNPALINELSAL

Download         Length: 297 bp

>AT170333 NZ_CP077290:c4704830-4704679 [Enterobacter cancerogenus]
CTTTCTTACAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGC
TAAAAGTTGGCATTAATGCAGGCTCAATCGCCTTGCACTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N1NNR7

Antitoxin

Source ID Structure

References