Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2949506..2950001 Replicon chromosome
Accession NZ_CP060401
Organism Xenorhabdus nematophila strain SII

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H8F46_RS12820 Protein ID WP_081480213.1
Coordinates 2949506..2949700 (+) Length 65 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H8F46_RS12825 Protein ID WP_010848973.1
Coordinates 2949702..2950001 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F46_RS12790 2944863..2945204 - 342 WP_013183347.1 hypothetical protein -
H8F46_RS12795 2945213..2945921 + 709 Protein_2501 transposase -
H8F46_RS12800 2946125..2946898 + 774 WP_010848977.1 amino acid ABC transporter substrate-binding protein -
H8F46_RS12805 2947182..2947898 + 717 WP_010848976.1 amino acid ABC transporter permease -
H8F46_RS12810 2947876..2948640 + 765 WP_010848975.1 amino acid ABC transporter ATP-binding protein -
H8F46_RS12815 2948694..2949482 + 789 WP_010848974.1 amino acid ABC transporter substrate-binding protein -
H8F46_RS12820 2949506..2949700 + 195 WP_081480213.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H8F46_RS12825 2949702..2950001 + 300 WP_010848973.1 XRE family transcriptional regulator Antitoxin
H8F46_RS12830 2950124..2950396 - 273 WP_081990835.1 hypothetical protein -
H8F46_RS12835 2950429..2951394 - 966 WP_010848971.1 PDR/VanB family oxidoreductase -
H8F46_RS12840 2951573..2952715 - 1143 WP_041979620.1 transposase -
H8F46_RS12845 2952772..2953200 + 429 WP_038218908.1 IS200/IS605 family transposase -
H8F46_RS12850 2953251..2954684 - 1434 WP_013183340.1 NAD-dependent succinate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-55)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-80)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7507.59 Da        Isoelectric Point: 8.5012

>T170327 WP_081480213.1 NZ_CP060401:2949506-2949700 [Xenorhabdus nematophila]
IDYISIDCSLYTRTIRAFFAFDPERQAVVFCAGNKAGKNQKSFYRDMIKVADEQFRIHLNNLEK

Download         Length: 195 bp

>T170327 NZ_CP077290:c2089048-2088098 [Enterobacter cancerogenus]
ATGGCTGATTTAATAAAGTTATTCCCTGATGTTGCCGATGCCCTGGGCATTGAATCAGTTGCAATTGTAGAGAAAGATTA
TTACATCGTTGAGTTATTGCGATTGCTCCAGCCTCTGGCGTTTGACACGCATCAACTGGTTTTTGCCGGTGGAACGGCAT
TGTCAAAAGCGGGGATATCTTTGAACAGGATGTCGGAGGACGTGGACATTAAGCTTGTTCCTGTCGCCGGTATTTCCCAG
CAATATTCCAGAGGTAAGCGTAAAAGCATTCGTAAGGGTATTATTCAGACCATTATCGAAACGATTGCAGCCTCAGATAC
GTTTCGCATGGATGAAGAGTATCCAAAGGTTACTCGTGATGAATATCGCTATAATGAAATTCCGGTACGCTACCCGCAGG
AATATGCACAAATTCCCTGTTTAAGGCCATTTATCAAACTGGAACTGATGGAAACGGATTTGCTTGAGGCTGCGGAAAAT
CGTGCTATTAGCTCACTGGTAATGGATCTAACAAAGAAGGGCGAAGTAGTGAGGGCTTTTCCCTGCGCAACTATCGGTAG
CACGCAGGCTGAAAAACTGATCTCGATGATGCGCAGAACGGCTGCAAGCGTGCGTAATGTGGAGCGTGCAGTGGATGAGT
CACTGGTGCGTCATATCTACGACAACTTTTGTATTGTCAGAGAAAAAGGTGCTGACGTTCCTGTTTTGAAGCGCTTTGTG
CAGGAATGTATTGAGCAGGATATCCAACGTTACGGTGCTCAGTATCCTGAATTCTGCGAGTCGCCTGTTGAAGAACTAAA
AATGGGGTTGGAAGAACTGGCGAGCAACCCTGTTTATAAGGAACGCTATCTGCAGTTTGTTACACCAATGGTGTTCGGTG
AAAGCCACGTTTCCTGGGAAGAGGCCTATGCCTGTTTTCGCATAACGGCATTGGATGTGATTGATGCATAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10868.74 Da        Isoelectric Point: 8.4812

>AT170327 WP_010848973.1 NZ_CP060401:2949702-2950001 [Xenorhabdus nematophila]
MATLKELMAKRSPESQAKIEEKAAEMLLETQLYQIREALALSQTQVAKNLGIAQSSVAAIEQRGNELKISTLKKYIEAMG
GEMTLGVKLPDGKLMNFSI

Download         Length: 300 bp

>AT170327 NZ_CP077290:c2089436-2089041 [Enterobacter cancerogenus]
ATGACCATAAAAGCTCGAATTCAGTCACGGCTGAAGCGCTCAAAGCGTTATGTTTTCACTCGTGACGATTTCAAAGATCT
TGCTGGCTACGATCAAATAGGCAGAGCACTGCGTGAGCTGATGAAGGAAGGGCAGCTACTGAAAGTAGGCTATGGCGTCT
ACACCAAAGCGCGGCAAAATGCGATTACCGGTAAGCTGATGCCTGCTGCTCCCGGAGGTTCTGCTGCGGTAATGATTGAG
GCGTTGGAACGTCTGAAAGTGGATTACCGTCTGGCAGGCGCAACAAGCGCCTATAATAGCGGTAAATCCACCCAGATCCC
TGCGTTAGTGGAAATCAAAACCTCACCACGTTTTAAGAGAACATTGTCAGTAGGGAACAGCAAATTAAATGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References