Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5139644..5140233 Replicon chromosome
Accession NZ_CP060399
Organism Xanthomonas hortorum pv. vitians strain LM16734

Toxin (Protein)


Gene name graT Uniprot ID A0A6V7BZM8
Locus tag XHV734_RS22060 Protein ID WP_074058684.1
Coordinates 5139952..5140233 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0Q5FN17
Locus tag XHV734_RS22055 Protein ID WP_055829449.1
Coordinates 5139644..5139934 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XHV734_RS22035 5135073..5136398 + 1326 WP_187433716.1 hypothetical protein -
XHV734_RS22040 5136791..5137123 + 333 WP_074058681.1 hypothetical protein -
XHV734_RS22045 5137741..5138643 - 903 WP_074058682.1 AraC family transcriptional regulator -
XHV734_RS22050 5138778..5139521 + 744 WP_074058683.1 SDR family oxidoreductase -
XHV734_RS22055 5139644..5139934 - 291 WP_055829449.1 HigA family addiction module antidote protein Antitoxin
XHV734_RS22060 5139952..5140233 - 282 WP_074058684.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XHV734_RS22065 5140448..5141503 - 1056 WP_074058685.1 virulence RhuM family protein -
XHV734_RS22070 5141642..5143885 - 2244 WP_154845001.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11031.71 Da        Isoelectric Point: 10.2121

>T170321 WP_074058684.1 NZ_CP060399:c5140233-5139952 [Xanthomonas hortorum pv. vitians]
MIRSFVDKEAEKIWLGERSRRLPADIQSVARRKLRMLNAAAHLDDLRIPPANRLEALKGQRRGQYSIRINDQWRICFRWM
EGDVAEVDIVDYH

Download         Length: 282 bp

>T170321 NZ_CP077279:c4388555-4388145 [Klebsiella quasipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCTCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GACTGGGAGATCCTTGGGACGCCATGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10497.17 Da        Isoelectric Point: 6.4675

>AT170321 WP_055829449.1 NZ_CP060399:c5139934-5139644 [Xanthomonas hortorum pv. vitians]
MTVLPNIHPGEILLEEFLEPMGISQNALARATAVPPRRINEIVLGKRGITADTAVRLAAALGTTERFWLGLQADYELEEA
HRALGDLPSRIKRLAA

Download         Length: 291 bp

>AT170321 NZ_CP077279:c4388802-4388536 [Klebsiella quasipneumoniae]
ATGGACATTAACAATAAAGCTCGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TATTCAACTGGCTGATGAACCATGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6V7BZM8

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q5FN17

References