Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2701736..2702251 Replicon chromosome
Accession NZ_CP060399
Organism Xanthomonas hortorum pv. vitians strain LM16734

Toxin (Protein)


Gene name higB Uniprot ID A0A1L5Y3A2
Locus tag XHV734_RS11600 Protein ID WP_006450902.1
Coordinates 2702045..2702251 (-) Length 69 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6V7E8T8
Locus tag XHV734_RS11595 Protein ID WP_074057535.1
Coordinates 2701736..2702035 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XHV734_RS11570 2697217..2698101 + 885 WP_006451802.1 MinD/ParA family protein -
XHV734_RS11575 2698098..2698871 + 774 WP_023903918.1 RNA polymerase sigma factor FliA -
XHV734_RS11580 2698907..2699299 + 393 WP_002813536.1 chemotaxis response regulator CheY -
XHV734_RS11585 2699299..2699925 + 627 WP_006450905.1 protein phosphatase CheZ -
XHV734_RS11590 2699928..2701586 + 1659 WP_055826896.1 chemotaxis protein CheA -
XHV734_RS11595 2701736..2702035 - 300 WP_074057535.1 HigA family addiction module antidote protein Antitoxin
XHV734_RS11600 2702045..2702251 - 207 WP_006450902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XHV734_RS11605 2703163..2703903 + 741 WP_006452732.1 flagellar motor protein -
XHV734_RS11610 2703911..2704900 + 990 WP_006452731.1 flagellar motor protein MotD -
XHV734_RS11615 2704902..2705684 + 783 WP_006452730.1 ParA family protein -
XHV734_RS11620 2705681..2706931 + 1251 WP_074057536.1 chemotaxis protein CheW -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-68)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-67)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7818.83 Da        Isoelectric Point: 6.2041

>T170318 WP_006450902.1 NZ_CP060399:c2702251-2702045 [Xanthomonas hortorum pv. vitians]
MQAVAERKLQLLDSAQTLEFLRSPPGNRFELLAGTRAGQHSIRINDQWRVCFVWTDAGPEHVEIVDYH

Download         Length: 207 bp

>T170318 NZ_CP077279:c1215506-1215288 [Klebsiella quasipneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGCCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAACAAATATGAACTTTCTGATAATGAGCTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAAATCCCGACGTCCGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10900.54 Da        Isoelectric Point: 10.7753

>AT170318 WP_074057535.1 NZ_CP060399:c2702035-2701736 [Xanthomonas hortorum pv. vitians]
MRPNNKLRAIHPGEILREDFMLPLGLTINGLARALDVPATRIHSIVHGERAISADTAARLARHFGGDAASWLALQATYEL
KTLPNRSEIERNVQPRVAA

Download         Length: 300 bp

>AT170318 NZ_CP077279:c1215907-1215533 [Klebsiella quasipneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCACAACTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACATCGGCTGTCAATCTCCAGTTAAATGAACTGATCGAGC
ACATTGCCACATTCGCCCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACATTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGGTT
ATTTCGTTGTTTTGTCAACGCCAGCCGGGAAAATCCGGCCAGTCTTTCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L5Y3A2

Antitoxin

Source ID Structure
AlphaFold DB A0A6V7E8T8

References