Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3028032..3028613 Replicon chromosome
Accession NZ_CP060397
Organism Synechococcus sp. CBW1004

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag H8F25_RS14320 Protein ID WP_197210981.1
Coordinates 3028032..3028310 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H8F25_RS14325 Protein ID WP_197210982.1
Coordinates 3028320..3028613 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F25_RS14300 3023228..3023605 - 378 WP_197210978.1 hypothetical protein -
H8F25_RS14305 3024770..3025639 + 870 WP_197210979.1 type I restriction-modification system subunit M N-terminal domain-containing protein -
H8F25_RS14310 3025554..3026537 + 984 WP_197210200.1 IS5 family transposase -
H8F25_RS14315 3026740..3027990 + 1251 WP_197210980.1 N-6 DNA methylase -
H8F25_RS14320 3028032..3028310 + 279 WP_197210981.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H8F25_RS14325 3028320..3028613 + 294 WP_197210982.1 HigA family addiction module antidote protein Antitoxin
H8F25_RS14330 3028619..3029023 + 405 WP_197210983.1 nucleotidyltransferase domain-containing protein -
H8F25_RS14335 3029020..3029307 + 288 WP_197210984.1 HEPN domain-containing protein -
H8F25_RS14340 3029407..3030672 + 1266 WP_197210985.1 restriction endonuclease subunit S -
H8F25_RS14345 3030676..3031629 + 954 WP_197210986.1 DUF4268 domain-containing protein -
H8F25_RS14350 3031626..3032669 + 1044 WP_197210987.1 DUF1016 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-68)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10938.39 Da        Isoelectric Point: 7.8670

>T170310 WP_197210981.1 NZ_CP060397:3028032-3028310 [Synechococcus sp. CBW1004]
MIRSFRCADTETLAQGWEVPRFQAFERVARRKLRQLEIAQRLEDLRVPPGNRLELLRGDRAGQHSIRINDQFRLCFRWSD
SGPEDVEIVDYH

Download         Length: 279 bp

>T170310 NZ_CP077265:1378747-1379232 [Klebsiella aerogenes]
ATGGGAAAAATAAGCGCGCCTGCACCGCTATCTTCACACCATCAGATCGCGGAATTTTGTTGTGGAGAAACGGTTCTCGA
TCAATGGCTGAAACAGCGAGGATTGAAAAACCAGGCTCAGGGCGCCGCGAGAACCTTTGTGGTCTGCAAGGAAGAGAGCC
ATCAGGTGGTGGGGTTTTATTCGTTAGCAACCGGCAGCGTTAATCACACGGAAGCCACTGGCGGCCTGCGGCGCAATATG
CCCGATCCTATCCCGGTCATCATTCTCGCCCGCCTGGCGATCGACTGCGCGTATCACGGACAGGGGCTGGGAGCTGATTT
ACTCCATGATGCGCTGTTACGCAGTTATCGCGTTGCCGAAAATGTTGGCGTACGTGCCCTGATGGTCCATGCCCTGACCG
ATAGCGCGAAAAGATTCTATTTACACCACGGATTCAAAGCCTCCACCACCCAGGAACGCACACTTTTCCTCGCGTTGCCT
AAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10656.28 Da        Isoelectric Point: 4.4488

>AT170310 WP_197210982.1 NZ_CP060397:3028320-3028613 [Synechococcus sp. CBW1004]
MDRLTPITPGELLLQEFLEPLGISQYRLAKAIDVPASRISEIITGQRAITADTDLRLCRVLGLSPGYWLRAQAAHDTEVA
SAELAEELERIQPLVGC

Download         Length: 294 bp

>AT170310 NZ_CP077265:1378493-1378759 [Klebsiella aerogenes]
ATGAAATCAGATATCCAACTCAACATCCGGGCGAAGGAGTCCCAGCGGGCGCTGATTGATGCGGCTGCCGAAATTCTGCA
CAAATCACGGACCGACTTTATTCTTGAGATGGCCTGCCAGGCGGCAGAAAACGTCATTCTCGACCGCCGGGTGTTTAACT
TAAGCGATGAGCAATACGCCGAATTTATCGACATGCTGGATGCGCCGGTTGAAGCTAACCCCGCTCTCGATAAATTGCTG
GCGAGAAAACCACAATGGGAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References