Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1973502..1973928 Replicon chromosome
Accession NZ_CP060397
Organism Synechococcus sp. CBW1004

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H8F25_RS09470 Protein ID WP_197210208.1
Coordinates 1973502..1973642 (+) Length 47 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H8F25_RS09475 Protein ID WP_197210209.1
Coordinates 1973632..1973928 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F25_RS09430 1969309..1970292 - 984 WP_197210200.1 IS5 family transposase -
H8F25_RS09435 1970359..1971069 - 711 WP_197210201.1 HNH endonuclease -
H8F25_RS09440 1971151..1971423 - 273 WP_197210202.1 hypothetical protein -
H8F25_RS09445 1971519..1971848 + 330 WP_197210203.1 adhesin -
H8F25_RS09450 1971852..1972085 + 234 WP_197210204.1 DUF4926 domain-containing protein -
H8F25_RS09455 1972205..1972468 - 264 WP_197210205.1 hypothetical protein -
H8F25_RS09460 1972618..1972821 + 204 WP_197210206.1 type II toxin-antitoxin system VapB family antitoxin -
H8F25_RS09465 1972818..1973225 + 408 WP_197210207.1 PIN domain-containing protein -
H8F25_RS09470 1973502..1973642 + 141 WP_197210208.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H8F25_RS09475 1973632..1973928 + 297 WP_197210209.1 HigA family addiction module antidote protein Antitoxin
H8F25_RS09480 1974008..1974361 - 354 WP_197213671.1 HNH endonuclease -
H8F25_RS09485 1975223..1976413 + 1191 WP_197210210.1 agmatinase -
H8F25_RS09490 1976417..1976806 + 390 WP_197210211.1 hydrogenase maturation nickel metallochaperone HypA -
H8F25_RS09495 1976809..1977528 + 720 WP_197210212.1 hydrogenase nickel incorporation protein HypB -
H8F25_RS09500 1977525..1978877 + 1353 WP_197210213.1 type III glutamate--ammonia ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-46)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-94)


Sequences

Toxin        


Download         Length: 47 a.a.        Molecular weight: 5351.02 Da        Isoelectric Point: 6.1986

>T170302 WP_197210208.1 NZ_CP060397:1973502-1973642 [Synechococcus sp. CBW1004]
MPPGNRLEPLRGNRHGQHSIRINDQFRLCFVWTEAGPEEVEIVDVH

Download         Length: 141 bp

>T170302 NZ_CP077264:2185661-2185879 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTTGAACGAGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAGC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTGTGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10881.72 Da        Isoelectric Point: 8.0493

>AT170302 WP_197210209.1 NZ_CP060397:1973632-1973928 [Synechococcus sp. CBW1004]
MSTDLLLVHPGEVLLAEFLRPMGISQYRLALAIGVPESRINAIVKGRRTISADTDLRLCRFFSLSEGFWLRMQASHDLKL
AKQALGGVLPSIEPFQSD

Download         Length: 297 bp

>AT170302 NZ_CP077264:2185259-2185633 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTCAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References