Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3227921..3228485 Replicon chromosome
Accession NZ_CP060396
Organism Synechococcus sp. CBW1006

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H8F26_RS15890 Protein ID WP_197155667.1
Coordinates 3228207..3228485 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H8F26_RS15885 Protein ID WP_197155661.1
Coordinates 3227921..3228202 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F26_RS15860 3223684..3224232 - 549 WP_197155642.1 restriction endonuclease subunit S -
H8F26_RS15865 3224281..3225315 + 1035 WP_197155644.1 IS5 family transposase -
H8F26_RS15870 3225752..3227215 - 1464 WP_197155649.1 N-6 DNA methylase -
H8F26_RS15875 3227212..3227598 - 387 WP_197155650.1 type II toxin-antitoxin system VapC family toxin -
H8F26_RS15880 3227622..3227882 - 261 WP_197155658.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
H8F26_RS15885 3227921..3228202 - 282 WP_197155661.1 HigA family addiction module antidote protein Antitoxin
H8F26_RS15890 3228207..3228485 - 279 WP_197155667.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H8F26_RS15895 3228556..3231912 - 3357 WP_197155672.1 type I restriction-modification system endonuclease -
H8F26_RS15900 3231909..3232640 - 732 WP_197155678.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-78)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10532.16 Da        Isoelectric Point: 8.1501

>T170300 WP_197155667.1 NZ_CP060396:c3228485-3228207 [Synechococcus sp. CBW1006]
VIRSFRCRDTLALFEGRPVRRFGSIARVACRKLAILDAAGCLNDLMIPPGNRLEPLRGDRHGQHSIRINDQFRLCFVWTE
AGPEEVEIVDYH

Download         Length: 279 bp

>T170300 NZ_CP077264:c1606195-1605674 [Enterobacter hormaechei]
GTGGCAAATCTCACGATCGAAATGTTATCAGAGGGAACCGATTACGATTTCGGCGATTTCGATTGTGGTGAACCCTCGCT
AAATGCCTTCCTTACCGAGCACCTGGTACGTCAGCACGGCGGGCGTATTTTACGCGGCTACCTGCTTAAAGAACGCGACC
ATCCGCGTGTCCTGGGCTATTACACACTCTCGGGAAGTTGCTTTGAAAAAGCGATGCTTCCTTCAAAGACTCAGCAGCGC
CGCATCCCATACAGCAACGTCCCCAGCGTGACGCTGGGGCGTCTGGCTGTCCATAAAGAACTCCAGGGAAACGAGTGGGG
AACAACGCTTGTCACACACGCTATGCGCGTTGTTTATCTGGCGTCGCAGGCTGTTGGCGTCCACGGAATTTTTGTGGATG
CGCTTAACGAACGGGCCAAACGATTTTATCTGAAGCTGGGGTTTATCCCGTTGGCAGGTGAAAACAGCAGTTCGCTGTTC
TTCCCCACGCAATCTATCGAACGACTGTTTGAGCAGTCGTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10310.18 Da        Isoelectric Point: 9.2008

>AT170300 WP_197155661.1 NZ_CP060396:c3228202-3227921 [Synechococcus sp. CBW1006]
MLVPPGEVLLEEFLRPMGVSQYRLALAIGVPESRINAIVKGRRAITADTDLRLCRFFGLSEGFWLRMQASHDLKLAKQAL
ASVLPAIEPLQHA

Download         Length: 282 bp

>AT170300 NZ_CP077264:c1606471-1606202 [Enterobacter hormaechei]
ATGCCAGCACTCAAAAAACAGCGTATCGATCTTCGCCTGTCGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACCAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCCGAAGTCATCGAACAGCATCGGCGTC
TCGTATTAAACGAAGCCTCATGGATTGCCGTTATGGATGCCATCGACAATCCGCCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References