Detailed information of TA system TA170238

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 27437..28091
• Replicon: chromosome
• Accession: NZ_CP060289
• Organism: Pseudomonas protegens strain H1F10A

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A7G8YM43
• Locus tag: GGD92_RS00115
• Protein ID: WP_016965723.1
• Coordinates: 27741..28091 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: GGD92_RS00110
• Protein ID: WP_179600748.1
• Coordinates: 27437..27754 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GGD92_RS00090	22740..23492	-	753	WP_016965728.1	UDP-2,3-diacylglucosamine diphosphatase	-
GGD92_RS00095	23489..23992	-	504	WP_016965727.1	peptidyl-prolyl cis-trans isomerase	-
GGD92_RS00100	24263..25963	+	1701	WP_179600746.1	glutamine--tRNA ligase/YqeY domain fusion protein	-
GGD92_RS00105	25982..27364	+	1383	WP_016965725.1	cysteine--tRNA ligase	-
GGD92_RS00110	27437..27754	-	318	WP_179600748.1	transcriptional regulator	Antitoxin
GGD92_RS00115	27741..28091	-	351	WP_016965723.1	hypothetical protein	Toxin
GGD92_RS00120	28330..29793	-	1464	WP_015636299.1	NADH-quinone oxidoreductase subunit NuoN	-
GGD92_RS00125	29801..31333	-	1533	WP_016965722.1	NADH-quinone oxidoreductase subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (48-101)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13980.08 Da
• Isoelectric Point: 8.9805

>T170238 WP_016965723.1 NZ_CP060289:c28091-27741 [Pseudomonas protegens]
MNALFIELPAFARYRRDFLDDELFCELQIELLRHPHAGVLIQGTGGLRKMRFVDERRNKGKRGGLRVIYYWWSGGAQFWL
FTLFDKEQMDDLLPQQRQQLKQLLEREIEARRHDQT

Nucleotide

• Length: 351 bp

>T170238 NZ_CP077214:c3652655-3651336 [Aeromonas sp. FDAARGOS 1411]
ATGGCCAATCTGGCTGTCTACATGAACGGCTATCGGGTAGGCACATTCACCAAAACTACCAGCGGCGCCCATCAATTTCA
GTACCGTGAATCATGGCTAGCACAACCGGGCAGCCGTCCGATCTCACTCTCCATGCCATTGCGCCATCAGCCCTACCGGG
GCGATGAAGCCTATAACTTCTTCGATAACCTGCTGCCAGATAATATGGAGGTGAGGAACAGGGTTGTAGCACGCTATCAA
GCGGCATCAACTCAGCCCTTCGATCTGCTCAGTTGCATTGGCCAGGATAGCGTAGGGGCATTACAGCTGGTTACCGAAGG
GCACGATGTTCCAGATGTCAGGCGAATCGACTACAAGGCACTTTCCGATGACGAGCTCGAGCAGATCCTGACCAGCTACA
AATCAGGAATCCCTTTGGGGATGGTCAGGGAGCAAGAGGAGTTCCGGATCTCTATCGCCGGGGCGCAAGAAAAGACTGCG
CTGCTCTATCTCGATGACCGTTGGTACTTGCCACTCAACGCAACGCCGACAACCCACATTATCAAACTCCCTATCGGCAA
GATTGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACTCTGATTGCCAAGGAGT
TTGGTCTACCCGTACCTCACTGCTTCATGATGCAGGTTGGCCAGGTCAAAGCACTGGCTGTGGAACGCTTCGACAGACGT
TACGCTGCCGATCGCAGTTGGATCATGCGCCTTCCCCAAGAAGATTTCTGTCAGGTATTGAATGTTCCGTCAGCACGGAA
ATACGAGAACCATGGAGGACCGGGGATCACTGACATCATGAAAACCTTGCTGGGCTCTGCGACACCAGAACAGGATCGCT
ACCTATTCATGAAATCTCAGGTCCTGTTCTGGCTGCTGGCGGCCACCGATGGCCATGCAAAAAACTTCTCGGTCTTTATT
GAGCCGGAAGGGCGTTTTCGCCTGACCCCTTTTTACGACATCCTATCTGTCTATCCAGTATTTGGCGGCCGAGGCCTCAA
CCGAAGGGACGCCAAGCTCGCTATGGGCCTAGCAAGCAGCAAGGGAAAGAAGTATGCCATTGAGCAGATATTCCCGCGTC
ATTTCTTCCAAACGGCGAAAGCTGTGGGATTTGAGCGTTCTGCTATGGAAGAGATCCTGACAGAACTGGCCAACTCCGTT
GATGATGTTATTGAGCGCGTTACCCAGCAATTGCCAGCAGACTTCCCCGATACCATCAGCAGCACCATTCTAGAGGGCCT
AAAAGCCCGCTCAGCCAGGCTGATAAAGGGTTGGGATTAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 12038.87 Da
• Isoelectric Point: 10.4439

>AT170238 WP_179600748.1 NZ_CP060289:c27754-27437 [Pseudomonas protegens]
MTKRDIFSELVEGIDALTQERQGKITLRSHKVKLDKLPPITAAEVMNIRQQLNLSRSVFAMYLRTNTRTLENWEQGRATP
NAQATTLIRLVERYPDTVERLASLA

Nucleotide

• Length: 318 bp

>AT170238 NZ_CP077214:c3652909-3652655 [Aeromonas sp. FDAARGOS 1411]
ATGAAAGTAACCAGCGCCAAGCAGCTGAGCGCCTGTATCAAGGATGCCAGGCTTTCTCAAAAGCTCTCTCAAGGCAAAGT
GGCCGAGAAAGTGGGGATTAGGCAAGACACAGTCTCCAGCTTCGAGCTCAATCCTGAATCCACCAAGCTGGAGACCCTGT
TCAAGATCCTCGCGGCACTCGAATTGTCACTAGACATCAAGCCCCGCAATGAGTCATCCGATAGTCCGGCATCGGGCTGG
AAGGAGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: A0A7G8YM43