Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 358777..359423 Replicon chromosome
Accession NZ_CP060281
Organism Klebsiella pneumoniae strain ent1077

Toxin (Protein)


Gene name higB Uniprot ID A0A231WWF9
Locus tag H7U30_RS01645 Protein ID WP_004174016.1
Coordinates 358777..359124 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A231WWU8
Locus tag H7U30_RS01650 Protein ID WP_004174017.1
Coordinates 359124..359423 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7U30_RS01635 354711..356144 + 1434 WP_002920564.1 glycogen synthase GlgA -
H7U30_RS01640 356162..358609 + 2448 WP_029884517.1 glycogen phosphorylase -
H7U30_RS01645 358777..359124 + 348 WP_004174016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7U30_RS01650 359124..359423 + 300 WP_004174017.1 XRE family transcriptional regulator Antitoxin
H7U30_RS01655 359486..360994 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
H7U30_RS01660 361199..361528 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
H7U30_RS01665 361579..362409 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
H7U30_RS01670 362459..363217 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13518.55 Da        Isoelectric Point: 6.2327

>T170212 WP_004174016.1 NZ_CP060281:358777-359124 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T170212 NZ_CP077205:1133316-1133705 [Acinetobacter pittii]
TTGATAAAAGAATTAAGTTTTGAGCTGAAATATAGCCGTGTCTCGGTAATATTTCAGCTTTTTGTTGGTTTGGGTTTAGC
AATCTTGCTTTATCAATTATTAACAGCTATATGGTGGCTATGTGCTGTCATTCTTCTATTTATTGGTTTTATTTTCTTTT
TAAAGCAAGCACAAATATCTCAAATTGAATATTTAGATCAAAAATTATGGTCGGTTGCATATTACTCGGAAAAAGAAATT
TACCGTGCGGAAATTAGAAAAATAATTGATTATCAGATGTTTGTAGTGATTTATTTTGAAGGGACATCTGCGAAAGCAAC
AACTGTTTGGTTCGATCAGCTTTCTTTTGAGCAGTGGAAAAGATTAAAAGTTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10844.64 Da        Isoelectric Point: 10.1464

>AT170212 WP_004174017.1 NZ_CP060281:359124-359423 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT170212 NZ_CP077205:1133052-1133309 [Acinetobacter pittii]
ATGTCTGACGAAATGACCTTGGAAGAACGTAAAGTAATTTATCGAGCACGCCGCGGCTTAAAAGAAATTGACGTCTATTT
TGACCCGTATGTAAAAAACTATTATTTAAAAGCTGATCCGGCAGAAAAAGCATTATTTGCAGAGTTAGTTGATCAAGAAG
ATCCAGATTTATTAGATTGGTTCATGGAAGTTTCTGAGCCTCCACGTACTGAGTTACGTGAATTTATTTATAAATTAAAA
CAGTATGTACATGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A231WWF9

Antitoxin

Source ID Structure
AlphaFold DB A0A231WWU8

References