Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 332595..333181 Replicon chromosome
Accession NZ_CP060281
Organism Klebsiella pneumoniae strain ent1077

Toxin (Protein)


Gene name doc Uniprot ID A0A7Z9B6M3
Locus tag H7U30_RS01535 Protein ID WP_029884514.1
Coordinates 332813..333181 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag H7U30_RS01530 Protein ID WP_004174006.1
Coordinates 332595..332816 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7U30_RS01510 328752..329678 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
H7U30_RS01515 329675..330952 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
H7U30_RS01520 330949..331716 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
H7U30_RS01525 331718..332431 + 714 WP_029884513.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
H7U30_RS01530 332595..332816 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
H7U30_RS01535 332813..333181 + 369 WP_029884514.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
H7U30_RS01540 333454..334770 + 1317 WP_029884515.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
H7U30_RS01545 334877..335764 + 888 WP_004901104.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
H7U30_RS01550 335761..336606 + 846 WP_004901101.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
H7U30_RS01555 336608..337678 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 329675..338415 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(6-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13583.01 Da        Isoelectric Point: 8.6410

>T170211 WP_029884514.1 NZ_CP060281:332813-333181 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRMALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T170211 NZ_CP077201:c1485473-1484154 [Aeromonas sp. FDAARGOS 1402]
ATGGCCAATCTGGCTGTCTACATGAACGGCTATCGGGTAGGCACATTCACCAAAACTACCAGCGGCGCCCATCAGTTTCA
GTACCATGAGTCATGGCTAGCACAACCGGGCAGCCGTCCGATCTCACTCTCCATGCCATTGCGCCATCAGGCCTACCGGG
GCGATGAAGCCTATAACTTCTTCGACAACCTGCTGCCAGATAATACGGAGGTGAGAAACAGGGTTGTAGCACGCTATCAA
GCGGCATCAACCCAGCCCTTCGATCTGCTCAGTTGCATTGGCCAGGATAGCGTAGGGGCATTACAGCTGGTTACCGAAGG
GCACGATGTTCCAGATGTCAGGCGAATCGACTACAAGGCACTTTCCGATGACGAGCTCGAGCAGATCCTGACCAGCTACA
AATCAGGAATCCCTTTGGGGATGGTCAGGGAGCAAGAGGAGTTCCGGATCTCTATCGCCGGGGCGCAAGAAAAGACTGCG
CTGCTCTATATCGATGGCCGTTGGTACTTGCCACTCAAAGCAACGCCGACAACCCACATTATCAAACTCCCTATCGGCAA
GATTGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACTCTGATTGCCAAGGAGT
TTGGTCTACCCGTACCTCACTGCTTCATGATGCAGGTTGGCCAGGTCAAAGCACTGGCTGTGGAACGCTTCGACAGACGT
TACGCTGCCGATCGCAGTTGGATAATGCGCCTTCCCCAAGAAGATTTCTGTCAGGTATTGAATGTTCCGTCAGCACGGAA
ATACGAGAGCCATGGAGGACCAGGGATCACAGACATCATGAAAACCTTGCTGGGCTCTGCGACACCAGAACAGGATCGCT
ACCTGTTCATGAAATCTCAGGTCCTGTTCTGGCTGCTGGCAGCCACCGATGGCCATGCAAAGAACTTCTCGGTCTTTATT
GAACCGGAAGGGCGTTTTCGCCTGACCCCTTTTTACGACATCCTATCTGTCTATCCAGTGTTTGGTGGCCGAGGCCTCAA
CCGAAGGGACGCCAAGCTCGCTATGGGCCTAGCAAGCAGCAAGGGAAAGAAGTACTCCATTGAGCAGATATTCCCGCGTC
ATTTCTTCCAAACGGCAAAAACTGTGGGATTTGAGCGTTCTGCTATGGAAGAGATCCTGACAGAACTGGCCAACTCCGTT
GATGATGTTATTGAGCGCGTTACCCAGCAATTGCCAGCAGACTTCCCCGATACCATCAGCAGCACCATTCTAGAGGGCCT
AAAAGCCCGCTCAGCCAGGCTGATAAAGGGTTGGGATTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT170211 WP_004174006.1 NZ_CP060281:332595-332816 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT170211 NZ_CP077201:c1485727-1485473 [Aeromonas sp. FDAARGOS 1402]
ATGAAAGTAACCAGCGCCAAGCAGCTGAGCGCCTGTATCAAGGATGCCAGGCTTTCTCAAAAGCTCTCTCAAGGCAAAGT
GGCCGAGAAAGTGGGGATTAGGCAAGACACAGTCTCCAGCTTCGAGCTCAATCCTGAGTCCACCAAGCTGGAAACCCTGT
TCAAGATCCTCGCAGCACTCGAATTGTCAGTGGATATCAAACCCCGCAATGAGTCATCCGAGAGTCCGGCATCGGGCTGG
AAGGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z9B6M3

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References