Detailed information of TA system TA170207

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2581202..2581418
• Replicon: chromosome
• Accession: NZ_CP060278
• Organism: Staphylococcus aureus strain KZN

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: H7684_RS12720
• Protein ID: WP_001802298.1
• Coordinates: 2581314..2581418 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2581202..2581257 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7684_RS12700	2577351..2578016	-	666	WP_001024095.1	SDR family oxidoreductase	-
H7684_RS12705	2578168..2578488	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
H7684_RS12710	2578490..2579467	+	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
H7684_RS12715	2579733..2580824	+	1092	WP_000495669.1	hypothetical protein	-
-	2581202..2581257	+	56	-	-	Antitoxin
H7684_RS12720	2581314..2581418	-	105	WP_001802298.1	hypothetical protein	Toxin
H7684_RS12725	2581935..2582105	+	171	WP_001792292.1	transposase	-
H7684_RS12730	2582098..2582256	+	159	WP_001792784.1	hypothetical protein	-
H7684_RS12735	2582914..2583771	-	858	WP_031769139.1	HAD family hydrolase	-
H7684_RS12740	2583839..2584621	-	783	WP_000908182.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T170207 WP_001802298.1 NZ_CP060278:c2581418-2581314 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T170207 NZ_CP077198:c610775-610485 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT170207 NZ_CP060278:2581202-2581257 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin