Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 78874..79391 Replicon chromosome
Accession NZ_CP060278
Organism Staphylococcus aureus strain KZN

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag H7684_RS00390 Protein ID WP_000113265.1
Coordinates 78874..79140 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag H7684_RS00395 Protein ID WP_000584499.1
Coordinates 79140..79391 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7684_RS00360 (74302) 74302..74838 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
H7684_RS00365 (75072) 75072..75896 - 825 WP_000572038.1 formate/nitrite transporter family protein -
H7684_RS00370 (76113) 76113..76295 - 183 WP_000230292.1 hypothetical protein -
H7684_RS00375 (76379) 76379..76846 - 468 WP_000153347.1 SRPBCC domain-containing protein -
H7684_RS00380 (77032) 77032..78579 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
H7684_RS00385 (78768) 78768..78839 - 72 Protein_76 hypothetical protein -
H7684_RS00390 (78874) 78874..79140 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
H7684_RS00395 (79140) 79140..79391 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
H7684_RS00400 (79556) 79556..79636 - 81 WP_223197974.1 hypothetical protein -
H7684_RS00405 (79664) 79664..80263 - 600 WP_000162810.1 DsbA family protein -
H7684_RS00410 (80282) 80282..80644 - 363 WP_000819843.1 DUF4467 domain-containing protein -
H7684_RS00415 (80899) 80899..82149 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
H7684_RS00420 (82246) 82246..82977 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
H7684_RS00425 (82974) 82974..83693 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T170193 WP_000113265.1 NZ_CP060278:c79140-78874 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T170193 NZ_CP077098:c2318368-2318264 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT170193 WP_000584499.1 NZ_CP060278:c79391-79140 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT170193 NZ_CP077098:2318170-2318208 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References