Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4531028..4531758 Replicon chromosome
Accession NZ_CP060276
Organism Serratia ureilytica strain CC119

Toxin (Protein)


Gene name higB Uniprot ID A0A8B4GR63
Locus tag D0895_RS21405 Protein ID WP_004937033.1
Coordinates 4531028..4531339 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D0895_RS21410 Protein ID WP_089192287.1
Coordinates 4531336..4531758 (+) Length 141 a.a.

Genomic Context

D0895_RS21375D0895_RS21380D0895_RS21385D0895_RS21390D0895_RS21395D0895_RS21400D0895_RS21405D0895_RS21410D0895_RS21415D0895_RS21420D0895_RS21425
Location: 4526343..4527068 (726 bp)
Type: Others
Protein ID: WP_004937040.1
Location: 4527121..4528554 (1434 bp)
Type: Others
Protein ID: WP_004937039.1
Location: 4528578..4528865 (288 bp)
Type: Others
Protein ID: WP_004937038.1
Location: 4529021..4529482 (462 bp)
Type: Others
Protein ID: WP_016930212.1
Location: 4529610..4530464 (855 bp)
Type: Others
Protein ID: WP_015379177.1
Location: 4530461..4530733 (273 bp)
Type: Others
Protein ID: WP_004937034.1
Location: 4531028..4531339 (312 bp)
Type: Toxin
Protein ID: WP_004937033.1
Location: 4531336..4531758 (423 bp)
Type: Antitoxin
Protein ID: WP_089192287.1
Location: 4531765..4533681 (1917 bp)
Type: Others
Protein ID: WP_033644486.1
Location: 4533733..4534947 (1215 bp)
Type: Others
Protein ID: WP_072626914.1
Location: 4535035..4535775 (741 bp)
Type: Others
Protein ID: WP_187048420.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
D0895_RS213754526343..4527068+726WP_004937040.1LPS export ABC transporter ATP-binding protein-
D0895_RS213804527121..4528554+1434WP_004937039.1RNA polymerase factor sigma-54-
D0895_RS213854528578..4528865+288WP_004937038.1ribosome hibernation promoting factor-
D0895_RS213904529021..4529482+462WP_016930212.1PTS IIA-like nitrogen regulatory protein PtsN-
D0895_RS213954529610..4530464+855WP_015379177.1RNase adapter RapZ-
D0895_RS214004530461..4530733+273WP_004937034.1PTS phosphocarrier protein NPr-
D0895_RS214054531028..4531339+312WP_004937033.1type II toxin-antitoxin system HigB family toxinToxin
D0895_RS214104531336..4531758+423WP_089192287.1helix-turn-helix domain-containing proteinAntitoxin
D0895_RS214154531765..4533681-1917WP_033644486.1BglG family transcription antiterminator-
D0895_RS214204533733..4534947-1215WP_072626914.1lactonase family protein-
D0895_RS214254535035..4535775-741WP_187048420.1KDGP aldolase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(81-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12289.14 Da        Isoelectric Point: 10.0957

>T170190 WP_004937033.1 NZ_CP060276:4531028-4531339 [Serratia ureilytica]
MHIISREPFNNATKQYPNEATALEAIYKALRRGEFRTPDELKALFPSLDRMKYKEKWWVIDVGGNHLRILFFASFETQKV
FIKHIVSHAEYDKLMQHYRRSSS

Download         Length: 312 bp

>T170190 NZ_CP077098:c2188035-2187715 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGATATTGAAGTGGTAAAAGAAAAAATAAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGATAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15752.07 Da        Isoelectric Point: 5.2060

>AT170190 WP_089192287.1 NZ_CP060276:4531336-4531758 [Serratia ureilytica]
MITDAIKAADALLRAVPLLQGSHAQQDYRDALELVEYLLENDERHPLIDLLAKKIAEYEDNSAEFTAFNQRIAQLPQGVA
ALRVLMEQHQLSQSDFEHEIGKKSLVNQILNGKRSLTIPHIMALAKRFNLPPALFLPEAD

Download         Length: 423 bp

>AT170190 NZ_CP077098:c2188247-2188038 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A8B4GR63

Antitoxin

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Source
ID
Structure
No matching records found

References