Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4028625..4029277 Replicon chromosome
Accession NZ_CP060276
Organism Serratia ureilytica strain CC119

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag D0895_RS19190 Protein ID WP_033652133.1
Coordinates 4028625..4028969 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D0895_RS19195 Protein ID WP_025304078.1
Coordinates 4028975..4029277 (+) Length 101 a.a.

Genomic Context

D0895_RS19185D0895_RS19190D0895_RS19195D0895_RS19205D0895_RS19215D0895_RS19220D0895_RS19180D0895_RS19200D0895_RS19210
Location: 4027447..4028466 (1020 bp)
Type: Others
Protein ID: WP_033652132.1
Location: 4028625..4028969 (345 bp)
Type: Toxin
Protein ID: WP_033652133.1
Location: 4028975..4029277 (303 bp)
Type: Antitoxin
Protein ID: WP_025304078.1
Location: 4030701..4031624 (924 bp)
Type: Others
Protein ID: WP_047026615.1
Location: 4032669..4033553 (885 bp)
Type: Others
Protein ID: WP_047026616.1
Location: 4033622..4034269 (648 bp)
Type: Others
Protein ID: WP_033644834.1
Location: 4024968..4027226 (2259 bp)
Type: Others
Protein ID: WP_187048327.1
Location: 4029305..4030567 (1263 bp)
Type: Others
Protein ID: WP_033644838.1
Location: 4031652..4032560 (909 bp)
Type: Others
Protein ID: WP_033644836.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
D0895_RS191804024968..4027226-2259WP_187048327.1molybdopterin guanine dinucleotide-containing S/N-oxide reductase-
D0895_RS191854027447..4028466+1020WP_033652132.1HTH-type transcriptional regulator GalR-
D0895_RS191904028625..4028969+345WP_033652133.1type II toxin-antitoxin system RelE/ParE family toxinToxin
D0895_RS191954028975..4029277+303WP_025304078.1helix-turn-helix transcriptional regulatorAntitoxin
D0895_RS192004029305..4030567-1263WP_033644838.1diaminopimelate decarboxylase-
D0895_RS192054030701..4031624+924WP_047026615.1LysR family transcriptional regulator-
D0895_RS192104031652..4032560-909WP_033644836.1LysR family transcriptional regulator-
D0895_RS192154032669..4033553+885WP_047026616.1MBL fold metallo-hydrolase-
D0895_RS192204033622..4034269+648WP_033644834.1DsbA family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

HigA2-like, helix-turn-helix domain

(29-89)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13325.36 Da        Isoelectric Point: 10.8296

>T170187 WP_033652133.1 NZ_CP060276:4028625-4028969 [Serratia ureilytica]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLARPHADTLHFSDAARQLKELRVQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

>T170187 NZ_CP077098:c1983292-1983140 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11081.01 Da        Isoelectric Point: 10.3986

>AT170187 WP_025304078.1 NZ_CP060276:4028975-4029277 [Serratia ureilytica]
MAKPLSQLIDKLDPAVVAAARQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp

>AT170187 NZ_CP077098:c1983916-1983317 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References