Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3295668..3296328 Replicon chromosome
Accession NZ_CP060276
Organism Serratia ureilytica strain CC119

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag D0895_RS15720 Protein ID WP_187048203.1
Coordinates 3295975..3296328 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8G2G5Z5
Locus tag D0895_RS15715 Protein ID WP_016927038.1
Coordinates 3295668..3295970 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0895_RS15695 3291282..3292196 - 915 WP_187048202.1 branched-chain amino acid ABC transporter permease LivH -
D0895_RS15700 3292321..3293439 - 1119 WP_016927040.1 branched-chain amino acid ABC transporter substrate-binding protein -
D0895_RS15710 3294045..3295253 - 1209 WP_089194949.1 aldose 1-epimerase family protein -
D0895_RS15715 3295668..3295970 - 303 WP_016927038.1 XRE family transcriptional regulator Antitoxin
D0895_RS15720 3295975..3296328 - 354 WP_187048203.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D0895_RS15725 3296767..3298062 + 1296 WP_033643756.1 MFS transporter -
D0895_RS15730 3298089..3298895 + 807 WP_047025353.1 substrate-binding domain-containing protein -
D0895_RS15735 3298870..3299769 - 900 WP_187048204.1 LysR family transcriptional regulator -
D0895_RS15740 3299872..3300237 - 366 WP_033643759.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13453.38 Da        Isoelectric Point: 8.2564

>T170186 WP_187048203.1 NZ_CP060276:c3296328-3295975 [Serratia ureilytica]
VWEIKTTDAFDHWFRSLSDADRAGVLAALMVLREKGAGLPRPYADTVKGSRYSNMKELRIQCRGEPLRAFFAFDPYCIGI
VLCAGNKAGNEKRFYDRMIQVADREFTNWLNTLNEKE

Download         Length: 354 bp

>T170186 NZ_CP077098:1922787-1922882 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.96 Da        Isoelectric Point: 6.4738

>AT170186 WP_016927038.1 NZ_CP060276:c3295970-3295668 [Serratia ureilytica]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDIELPDGSHYEFVL

Download         Length: 303 bp

>AT170186 NZ_CP077098:c1922969-1922910 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References