Detailed information of TA system TA170170

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 1818585..1819057
• Replicon: chromosome
• Accession: NZ_CP060271
• Organism: Staphylococcus xylosus strain DMSX03

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: DMSX03_RS08580
• Protein ID: WP_186335309.1
• Coordinates: 1818585..1818842 (-)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1818893..1819057 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DMSX03_RS08550	1814016..1814435	-	420	WP_186335304.1	MarR family transcriptional regulator	-
DMSX03_RS08555	1814554..1815525	+	972	WP_186335305.1	acryloyl-CoA reductase	-
DMSX03_RS08560	1815574..1815984	-	411	Protein_1655	YolD-like family protein	-
DMSX03_RS08565	1816186..1816830	-	645	WP_186335306.1	hypothetical protein	-
DMSX03_RS08570	1817210..1818157	-	948	WP_186335307.1	N-acetylmuramoyl-L-alanine amidase	-
DMSX03_RS08575	1818263..1818400	-	138	WP_186335308.1	hypothetical protein	-
DMSX03_RS08580	1818585..1818842	-	258	WP_186335309.1	phage holin	Toxin
-	1818893..1819057	+	165	-	-	Antitoxin
DMSX03_RS08585	1819018..1819195	-	178	Protein_1660	putative holin-like toxin	-
DMSX03_RS08590	1819277..1819558	-	282	WP_171915384.1	hypothetical protein	-
DMSX03_RS08595	1819593..1821479	-	1887	WP_186335310.1	glucosaminidase domain-containing protein	-
DMSX03_RS08600	1821535..1821867	-	333	WP_186335311.1	DUF2977 domain-containing protein	-
DMSX03_RS08605	1821867..1823726	-	1860	WP_186335312.1	phage baseplate upper protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1808111..1862075	53964

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (7-67)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9576.35 Da
• Isoelectric Point: 10.0540

>T170170 WP_186335309.1 NZ_CP060271:c1818842-1818585 [Staphylococcus xylosus]
MDVKVTVIVRVLGLILVLVNQWLSNKGISPIPVDESTLMTIAVALLTTWKDNPFTSAAKESNKMMKELKTQNKYEKVVMR
NGKEE

Nucleotide

• Length: 258 bp

>T170170 NZ_CP077093:c4425383-4424979 [Pseudomonas vanderleydeniana]
ATGCTCAAGTTCATGCTCGATACCAATATGTGCATCTTCACGATCAAGAATCGCCCTGAACAGGTTCGCGAGGCATTCAA
GCGGCACCATGGGCAGATGTGCATCAGCACTGTCACATTGATGGAGCTGATCTACGGCGCCGAGAAATCCTCGAACCCTG
AGCGTAATCTGGCTGATGTCGAGGGCTTCGCGGCACGCCTGGACGTGCTGGCTTATGATCAATCCGCAGCGGCACACACT
GGCCAGGTTCGTGCAGAGCTGGCCAGGGCGGGCCAACCCATTGGCCCCTACGATTACATGATTGCAGGGCATGCCCGCTC
CCAGGGACTTATTGTTGTCACCAATAACCGTCGCGAGTTTGACCGTGTACCGGGTCTGCGAGTTGAGGATTGGGCTGCCA
GTTGA

Antitoxin

Nucleotide

• Length: 165 bp

>AT170170 NZ_CP060271:1818893-1819057 [Staphylococcus xylosus]
ATTTGATAATATTTTTATGTTGTGTTAATTTATATATAGAAAAAGGGCAATACACCATAAGTGTATCGCCCAAATGAGCC
CGTTAAAAAGACGGTGGCTAGTTACTAATAATTATCAAAAAATAATCATCGAAACCGGCCAAAGTTAGCGATGGTTATTT
TTTAT

Structures

Antitoxin