Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1033468..1034063 Replicon chromosome
Accession NZ_CP060241
Organism Pseudomonas aeruginosa strain C-I-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6A80_RS04705 Protein ID WP_071538299.1
Coordinates 1033468..1033746 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6A80_RS04710 Protein ID WP_003123432.1
Coordinates 1033758..1034063 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6A80_RS04690 1028894..1030132 + 1239 WP_034076699.1 C69 family dipeptidase -
I6A80_RS04695 1030194..1030841 + 648 WP_003095021.1 carbonate dehydratase -
I6A80_RS04700 1030911..1033139 - 2229 WP_003113525.1 TonB-dependent receptor -
I6A80_RS04705 1033468..1033746 + 279 WP_071538299.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6A80_RS04710 1033758..1034063 + 306 WP_003123432.1 HigA family addiction module antidote protein Antitoxin
I6A80_RS04720 1034469..1035569 - 1101 WP_003099270.1 redox-regulated ATPase YchF -
I6A80_RS04725 1035610..1036194 - 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
I6A80_RS04730 1036236..1036850 - 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
I6A80_RS04735 1036967..1037908 - 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
I6A80_RS04745 1038075..1038923 - 849 WP_003123430.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10616.17 Da        Isoelectric Point: 7.8937

>T170109 WP_071538299.1 NZ_CP060241:1033468-1033746 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHGIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T170109 NZ_CP077083:3459902-3460780 [Pseudomonas salmasensis]
ATGCTGCCAGGACTCTCTCAAGCCGCGCCGCCGGCGGACCTGCAAGCCCAGCTGGAGCGCGATTTCCCCCAACGCCTGGT
GGCCTCGGCCGGTGGGCAACAGGCATTGCGTGAATGTGGCGCGGGGCCGGTGGTGGTGCTGCTGCACGGTATCGGCTCCG
GGGCGGCGTCCTGGCTGCAAGTGGCGCGGCAACTGGCGCCCCAGGCCCGGGTCATCGCCTGGGACGCTCCCGGCTACGGC
GATTCCAGCCCGCTGGAGTCGGATGCGCCCAAGGCAGAACAGTACGCAGCCCGTCTGGCGCAGATGTTGGATGCGCTGGG
TGTCGAGGAATGTGTGCTGGTCGGCCACTCCCTCGGCGCCCTCACCGCCCTGGCGTTCGCCCGCAGTTCACAGGCCCATC
GCGTCAACCGGCTGGTGCTGATCAGCCCGGCGCGCGGCTACGGCGCACCAGCCCTTGGCCAACAGCGCCAACAGGTGCGT
CAGCAACGCCTGGACAACCTGCAACGCCTGGGCATCGCCGGCCTGGCTGAACAACGCAGCGCTCACATGCTGTCGCCCCG
TGCCACGCTCCAAGCCCTGGCCTGGGTGCGTTGGAACATGGCGCGCCTGAACCCCGTTGGTTATCGCCAGGCCATTGAAT
TGCTGTGCGGCGATGACCTGCTGCGCCATGGCCAACCGGCCATGCCCTGCGAGGTGCATTGCGGTGAAGCCGACAGCATC
ACCCCCGCCGAGGCCTGCCTGAGCGTGGCCAAGGCGCTGGGCGCCAGCTTCAACCTGATTGCCGACGCCGGCCACGCCAG
CCCCATCGAGCAACCCCAAGTGGTAGCCGGGCGCCTGGCCTGCGCCATTCATCAATCCCTGACTGGTAGAACCCTATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11204.78 Da        Isoelectric Point: 4.7769

>AT170109 WP_003123432.1 NZ_CP060241:1033758-1034063 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAQG

Download         Length: 306 bp

>AT170109 NZ_CP077083:3460777-3461610 [Pseudomonas salmasensis]
ATGAACGATTCCGATCTGCTCAAAGACGCTCAGGACAAATACATCGTTCCAGGCCTGGAGCGCGGCCTGCTCCTGCTCTG
TGAGTTCAGCCGGCGCAACCGCACCCTGACCGCGCCCGAGCTGGCGCGTCGGTTGGCACTGCCCCGCTCGACCATTTTCC
GCCTGCTGACCACCCTGGAGACCATGGGCTTCGTCACCCGCAGCGGCAATGAATACCGCCTCGGCATGTCCGTGCTTCGC
CTGGGCTTCGAGTACCTGGCGTCGCTGGAGCTGACCGAACTGGGCCAGCCGTTGCTGGCGCGCTTGTGCGACCGGGTCAA
CTACCCGAGCAACCTGGTGGTGCGTGACGGTCGCTCGATTGTCTACGTGGCCAAGGTTTCGCCGCCTTCGGTGTTCTCCA
ACGCGGTCAACGTCGGCACCCGCCTGCCCGCCCATGCCACCGTGCTGGGGCGCATCCTGCTCGAAGACCTGTCGCTGGCC
GAGTTGCGTGAGCTGTACCCCGAAGAGCACCTGGAACAACACTCGCCTTGCACGCCGAAAACCGTGATGGCGCTGTTCGA
CCTGGTCCAGGCCGACCGCCAGCGCGGGTTTGTCAGCGGCGAAGGTTTTTTCGAATCGGCGATTTCTACCGTGGCCGCGC
CCGTGCGTGACCAGAGCGGCGGCATCGTCGCAGCCCTGGGCGTGACCATCCCCACGGCGCAAATCGGCCACGTCAACTTT
GAGGAACTCTTGAATCAGGTCCGGCGCAGCGCCGACGAGCTGTCACGCCTGCTCAACTACAACGGCGGCGCCCATAACGG
GCAGCCCCGCGTCACCGCCTTGATGAGAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References