Detailed information of TA system TA170062

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 1662645..1663120
• Replicon: chromosome
• Accession: NZ_CP060141
• Organism: Staphylococcus aureus strain 2868B2

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: H5U44_RS08340
• Protein ID: WP_000387655.1
• Coordinates: 1662818..1663120 (+)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1662645..1662769 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H5U44_RS08300	1657706..1657996	+	291	WP_000179860.1	hypothetical protein	-
H5U44_RS08305	1658012..1659922	+	1911	WP_000429548.1	hypothetical protein	-
H5U44_RS08310	1659922..1661388	+	1467	WP_000067150.1	BppU family phage baseplate upper protein	-
H5U44_RS08315	1661388..1661777	+	390	WP_001166602.1	DUF2977 domain-containing protein	-
H5U44_RS08320	1661770..1661934	+	165	WP_000916020.1	XkdX family protein	-
H5U44_RS08325	1661980..1662279	+	300	WP_000466781.1	DUF2951 family protein	-
H5U44_RS08330	1662513..1662620	+	108	WP_000253687.1	putative holin-like toxin	-
-	1662645..1662769	-	125	-	-	Antitoxin
H5U44_RS08340	1662818..1663120	+	303	WP_000387655.1	phage holin	Toxin
H5U44_RS08345	1663131..1664585	+	1455	WP_000930251.1	N-acetylmuramoyl-L-alanine amidase	-
H5U44_RS08350	1664930..1665478	+	549	WP_240140516.1	CPBP family intramembrane metalloprotease	-
H5U44_RS08355	1665748..1665849	+	102	Protein_1635	hypothetical protein	-
H5U44_RS08360	1666347..1667300	+	954	WP_000766912.1	ornithine cyclodeaminase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb	1604208..1664585	60377

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (1-71)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11127.85 Da
• Isoelectric Point: 9.6587

>T170062 WP_000387655.1 NZ_CP060141:1662818-1663120 [Staphylococcus aureus]
MEAKVITRYIVLILALVNQFLANKGISPIPVDEESVSSIILTVIALYTTYKDNPTSQEGRWANQKLKKYKAESKYRKATG
QAPVKEVIAPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T170062 NZ_CP077075:c426260-425976 [Pseudomonas xanthosomae]
ATGCATGTACTGACTTTCAGCCAGGCCCGCGCCGATCTGAAGCAAACGATGGATGACGTATGCCGGGATCACGAGCCGGC
CATCATCACCCGCCAGCGAGGTGAACCCGTGGTCATGCTGTCCCTCGAGGACTACAACGGGATGCAGGAGACTCTCTATC
TGCTGGGGTCCTCCGCTAACGCCAAGCGCTTGCGTGCGTCTATCGAACAGCTGCGGTCGGGTAAGCCTGCTACCCATGAG
CTGAAAATCGATGAACATGAAGTCAAAGCAACGCAACAAGACTGA

Antitoxin

Nucleotide

• Length: 125 bp

>AT170062 NZ_CP060141:c1662769-1662645 [Staphylococcus aureus]
ATTTGATATTTATATTATGATGTGTTAATTTATATATAGAAAAAGGGCAACATGCGGAAACATGTCACCCTAGTGAGCCC
GTTAAAAAGACGGTGACCTCTTTTATATGATTAATAAATAACCAT

Structures

Antitoxin