Detailed information of TA system TA170058

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1662513..1662738
• Replicon: chromosome
• Accession: NZ_CP060141
• Organism: Staphylococcus aureus strain 2868B2

Toxin (Protein)

• Gene name: SprG2
• Uniprot ID: -
• Locus tag: H5U44_RS08330
• Protein ID: WP_000253687.1
• Coordinates: 1662513..1662620 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1662645..1662738 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H5U44_RS08300 (1657706)	1657706..1657996	+	291	WP_000179860.1	hypothetical protein	-
H5U44_RS08305 (1658012)	1658012..1659922	+	1911	WP_000429548.1	hypothetical protein	-
H5U44_RS08310 (1659922)	1659922..1661388	+	1467	WP_000067150.1	BppU family phage baseplate upper protein	-
H5U44_RS08315 (1661388)	1661388..1661777	+	390	WP_001166602.1	DUF2977 domain-containing protein	-
H5U44_RS08320 (1661770)	1661770..1661934	+	165	WP_000916020.1	XkdX family protein	-
H5U44_RS08325 (1661980)	1661980..1662279	+	300	WP_000466781.1	DUF2951 family protein	-
H5U44_RS08330 (1662513)	1662513..1662620	+	108	WP_000253687.1	putative holin-like toxin	Toxin
- (1662645)	1662645..1662738	-	94	NuclAT_0	-	Antitoxin
- (1662645)	1662645..1662738	-	94	NuclAT_0	-	Antitoxin
- (1662645)	1662645..1662738	-	94	NuclAT_0	-	Antitoxin
- (1662645)	1662645..1662738	-	94	NuclAT_0	-	Antitoxin
H5U44_RS08335 (1662660)	1662660..1662767	-	108	Protein_1631	hypothetical protein	-
H5U44_RS08340 (1662818)	1662818..1663120	+	303	WP_000387655.1	phage holin	-
H5U44_RS08345 (1663131)	1663131..1664585	+	1455	WP_000930251.1	N-acetylmuramoyl-L-alanine amidase	-
H5U44_RS08350 (1664930)	1664930..1665478	+	549	WP_240140516.1	CPBP family intramembrane metalloprotease	-
H5U44_RS08355 (1665748)	1665748..1665849	+	102	Protein_1635	hypothetical protein	-
H5U44_RS08360 (1666347)	1666347..1667300	+	954	WP_000766912.1	ornithine cyclodeaminase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb	1604208..1664585	60377

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3844.80 Da
• Isoelectric Point: 10.4997

>T170058 WP_000253687.1 NZ_CP060141:1662513-1662620 [Staphylococcus aureus]
VVSIVDALNLMFSFGMFIVTLLGLVIAIVKLNHKK

Nucleotide

• Length: 108 bp

>T170058 NZ_CP077074:c5849065-5848667 [Pseudomonas sessilinigenes]
ATGTTCAAGTACATGCTCGATACCAATATCTGCATCTTTACCATCAAGAACAAACCCCAGCAGGTTCGCGAAGCGTTCAG
CCGTAATCAGGGGCGTTTGTGCATCAGTTCCATCACGTTGATGGAACTGATCTATGGTGCGGAAAAATCTGCCGTGCCGG
AGAAAAACCTGGGGCGTGTCGAAAGCTTCGTGGCACGCCTGCAAGTGCTGGATTATGACGATAACGCCGCGATCCATAGT
GGCCAGCTACAGGCCGAACTCGCCCAGAAGGGCAACCGAATAGGTCCCTACGATCAACTGATAGCGGGACATGCCAGGTC
ATTGGGGCTGACCCTGGTCACCAACAATCTTCGTGAGTTCGAGCGTGTGCCCGGGTTGCGCGTCGAGGATTGGGTCTAG

Antitoxin

Nucleotide

• Length: 94 bp

>AT170058 NZ_CP060141:c1662738-1662645 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGGAAACATGTCACCCTAGTGAGCCCGTTAAAAAGACGGTGACCTCTTTTATATGAT
TAATAAATAACCAT

Structures

Antitoxin