Detailed information of TA system TA170052

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1483011..1483289
• Replicon: chromosome
• Accession: NZ_CP060141
• Organism: Staphylococcus aureus strain 2868B2

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: H5U44_RS07315
• Protein ID: WP_001802298.1
• Coordinates: 1483011..1483115 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1483111..1483289 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H5U44_RS07300	1479808..1480590	+	783	WP_031590911.1	ABC transporter ATP-binding protein	-
H5U44_RS07305	1480658..1481515	+	858	WP_000370930.1	HAD family hydrolase	-
H5U44_RS07310	1482173..1482331	-	159	WP_001792784.1	hypothetical protein	-
H5U44_RS07315	1483011..1483115	+	105	WP_001802298.1	hypothetical protein	Toxin
-	1483111..1483289	-	179	-	-	Antitoxin
H5U44_RS07325	1483557..1484648	-	1092	WP_000495681.1	hypothetical protein	-
H5U44_RS07330	1484914..1485894	-	981	WP_000019743.1	CDF family zinc efflux transporter CzrB	-
H5U44_RS07335	1485896..1486216	-	321	WP_240140512.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
H5U44_RS07340	1486368..1487033	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T170052 WP_001802298.1 NZ_CP060141:1483011-1483115 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T170052 NZ_CP077074:c923591-923301 [Pseudomonas sessilinigenes]
ATGCGCACCCCAGTGACCCGCTTCGATGCGGCCGACTACCTCAAGACCCCGCAAGACATGGTGGCCTACCTCGATGCCTG
CTTCGAGGAAGATGCCGGCGATGGCGTGCTGATCCGCGCCGCCCTCAACGACATCGCCCGCGCCCGGGGCATGACCCAGA
TAGCCCGGGACACCGGCCTGGGCCGCGAAAGCCTGTACAAGGCGCTGGGCAGCCAGGGCAATCCCGAGTTCGCGACTATC
ATCAAGGTGATGAAGGCGCTGGGACTCAAGCTTCAGGTCAGCCCGGCCTGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT170052 NZ_CP060141:c1483289-1483111 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin