Detailed information of TA system TA170048

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1185673..1185857
• Replicon: chromosome
• Accession: NZ_CP060141
• Organism: Staphylococcus aureus strain 2868B2

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: H5U44_RS05740
• Protein ID: WP_000482647.1
• Coordinates: 1185673..1185780 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1185797..1185857 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H5U44_RS05715	1181045..1181518	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
H5U44_RS05720	1181641..1182852	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
H5U44_RS05725	1183034..1183693	-	660	WP_000831298.1	membrane protein	-
H5U44_RS05730	1183753..1184895	-	1143	WP_001176863.1	glycerate kinase	-
H5U44_RS05735	1185153..1185539	+	387	WP_000779360.1	flippase GtxA	-
H5U44_RS05740	1185673..1185780	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	1185797..1185857	-	61	-	-	Antitoxin
H5U44_RS05745	1186408..1188171	+	1764	WP_001064816.1	ABC transporter ATP-binding protein	-
H5U44_RS05750	1188196..1189929	+	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
H5U44_RS05755	1190160..1190327	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T170048 WP_000482647.1 NZ_CP060141:1185673-1185780 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T170048 NZ_CP077073:2501654-2501950 [Pseudomonas muyukensis]
ATGGAAAAGAGAACGCCTCATTGCTCACTTGCACGTGTGCATGCCCTGCTGGCTGAAGGCTTGGTGCGAATTACCCACAC
TGCGGCCAAAGGTGCTGCTGACCTGGGCATTAGTGAAGAGCAGTTACTGGCGGGTGTCGCGCAGCTTACCCGTGGCGACT
TTTACAAGAGCATGACCAGCTTTGCAGATCACCGCGTTTGGCATGATGTTTATCGTCCCATGACTCGAGTGGGCAGGGTG
TATCTCAAGCTGGTGGTAATCAATGACTTGCTCATTGTGTCTTTCAAGGAGCTGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT170048 NZ_CP060141:c1185857-1185797 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin