170009

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1518116..1519704 Replicon chromosome
Accession NZ_CP060121
Organism Escherichia coli BL21

Toxin (Protein)


Gene name hipA Uniprot ID S1ELM3
Locus tag FFHJCLDM_RS07435 Protein ID WP_001125439.1
Coordinates 1518116..1519438 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FFHJCLDM_RS07440 Protein ID WP_001301023.1
Coordinates 1519438..1519704 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFHJCLDM_RS07410 1513499..1514647 - 1149 WP_000017447.1 fimbrial biogenesis outer membrane usher protein -
FFHJCLDM_RS07415 1514711..1515844 - 1134 WP_001354080.1 fimbrial biogenesis outer membrane usher protein -
FFHJCLDM_RS07420 1515799..1516149 - 351 WP_001354079.1 usher protein -
FFHJCLDM_RS07425 1516191..1516901 - 711 Protein_1452 fimbria/pilus periplasmic chaperone -
FFHJCLDM_RS07430 1517262..1517744 - 483 WP_000931227.1 fimbrial protein -
FFHJCLDM_RS07435 1518116..1519438 - 1323 WP_001125439.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
FFHJCLDM_RS07440 1519438..1519704 - 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
FFHJCLDM_RS07445 1519927..1521507 - 1581 Protein_1456 autotransporter outer membrane beta-barrel domain-containing protein -
FFHJCLDM_RS07450 1521503..1522279 + 777 Protein_1457 histidine kinase -
FFHJCLDM_RS07455 1522291..1523313 + 1023 WP_000172488.1 autoinducer 2 ABC transporter substrate-binding protein LsrB -
FFHJCLDM_RS07460 1523340..1524215 + 876 WP_000774188.1 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase -
FFHJCLDM_RS07465 1524239..1524529 + 291 WP_000558527.1 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimC 1505488..1519704 14216


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49275.82 Da        Isoelectric Point: 8.2482

>T170009 WP_001125439.1 NZ_CP060121:c1519438-1518116 [Escherichia coli BL21]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

>T170009 NZ_CP076856:70523-70789 [Shewanella decolorationis]
TTGGCTTGGACAATTGATTACTCAGAACGAGCGCTAAAATCACTAAAAAAAATGGATAAGCAGAACGCTAAACGCATTCT
GGATTTTTTGGAACAGCGCATAGCGATATTGGACGATCCGAGAACGTCAGGAAAGCCCCTGAAGGGGGATTTGGGGATTT
TTTGGCGTTATCGAGTAGGTGACTATCGAGTACTTTGTGAAATTCAAGATAGCAAATTAGTCATTCTGACTGCTTTGATA
GGGCACAGGAAAGAGATCTATGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT170009 WP_001301023.1 NZ_CP060121:c1519704-1519438 [Escherichia coli BL21]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp

>AT170009 NZ_CP076856:70315-70539 [Shewanella decolorationis]
ATGTTAGCAATACGGTTACCTGATGATATTGAAACCCGTCTGGCTGCTTTGGCAGATCAAACCGGTAGAACAAAAACCTT
TTACGCCAGAGAAGCTATTTTGACTCATTTAGAAGATCTGGAGGATTACTATCTTGCGGCTCAGATTGTCTCTGATATTC
GTAAAGGGGCTGAAAAAACCTACAGTAGCGAAGATGTGAGGGCGTCACTTGGCTTGGACAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5K98
PDB 3TPV
PDB 3DNV
PDB 3TPD
PDB 3HZI
PDB 3FBR
PDB 4YG7
PDB 3TPE
PDB 2WIU
PDB 3DNT
PDB 3TPB
PDB 3TPT
PDB 3DNU

Antitoxin

Source ID Structure

References