Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 3239588..3240090 | Replicon | chromosome |
| Accession | NZ_CP060117 | ||
| Organism | Shigella sonnei strain UKMCC_1015 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | HYI41_RS16415 | Protein ID | WP_000767829.1 |
| Coordinates | 3239588..3239842 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | HYI41_RS16420 | Protein ID | WP_001259255.1 |
| Coordinates | 3239839..3240090 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HYI41_RS16385 (3234603) | 3234603..3234830 | - | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
| HYI41_RS16390 (3234844) | 3234844..3235902 | - | 1059 | WP_000492295.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| HYI41_RS16395 (3236081) | 3236081..3237439 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| HYI41_RS16400 (3237429) | 3237429..3237491 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
| HYI41_RS16405 (3237706) | 3237706..3238635 | - | 930 | WP_000811606.1 | LysR substrate-binding domain-containing protein | - |
| HYI41_RS16410 (3238681) | 3238681..3239505 | - | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| HYI41_RS16415 (3239588) | 3239588..3239842 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| HYI41_RS16420 (3239839) | 3239839..3240090 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| HYI41_RS16425 (3240373) | 3240373..3240423 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
| HYI41_RS16430 (3240569) | 3240569..3241468 | + | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| HYI41_RS16435 (3241474) | 3241474..3242778 | + | 1305 | WP_001462576.1 | histidinol dehydrogenase | - |
| HYI41_RS16440 (3242775) | 3242775..3243845 | + | 1071 | WP_000108977.1 | histidinol-phosphate transaminase | - |
| HYI41_RS16445 (3243845) | 3243845..3244912 | + | 1068 | WP_000080086.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T169990 WP_000767829.1 NZ_CP060117:c3239842-3239588 [Shigella sonnei]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T169990 NZ_CP076846:c1744244-1743975 [Agrobacterium pusense]
ATGAAGCTCGTCTGGACGCTGAGTTCATGGGACGATTACGAGTTCTGGCAAAGAACCGATGCTCGTATGGTAGAGAAAAT
TAACGACCTCATACGGAATGCCAAACGGACGCCCTTTGCTGGGCTCGGAAAACCGGAGCCTCTGAAGGGCGATATGGCAG
GATATTGGTCTCGGCGGATTTCCGCCGAGCATCGGTTTGTCTATCGTGTATCCGGGTCCGGCAGCGAACAAAGGCTGGAG
ATCATCCAGTGCCGCTTCCATTACCAGTAA
ATGAAGCTCGTCTGGACGCTGAGTTCATGGGACGATTACGAGTTCTGGCAAAGAACCGATGCTCGTATGGTAGAGAAAAT
TAACGACCTCATACGGAATGCCAAACGGACGCCCTTTGCTGGGCTCGGAAAACCGGAGCCTCTGAAGGGCGATATGGCAG
GATATTGGTCTCGGCGGATTTCCGCCGAGCATCGGTTTGTCTATCGTGTATCCGGGTCCGGCAGCGAACAAAGGCTGGAG
ATCATCCAGTGCCGCTTCCATTACCAGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT169990 WP_001259255.1 NZ_CP060117:c3240090-3239839 [Shigella sonnei]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT169990 NZ_CP076846:c1744495-1744241 [Agrobacterium pusense]
ATGGCAAATGTGCGATTCACGGAATTCCGGCAGAACTTCGCGACCCATTTCGACCGGGTTCTGGAGACGCGCGCGCCGTT
GCTGGTTACTCGGCAGGGGAAGGAGGCGGTCGTGGTTCTCGCTGAGGGGGAATACGAGAGCATGCAGGAAACGCTGCATC
TTTTATCCAACCCGGCAAATGCCTTACGACTTCGTACTTCCATGGATCAACTTGAACGCGGCGATATCATCGAGCGGGAT
CCAACCGAAGAATGA
ATGGCAAATGTGCGATTCACGGAATTCCGGCAGAACTTCGCGACCCATTTCGACCGGGTTCTGGAGACGCGCGCGCCGTT
GCTGGTTACTCGGCAGGGGAAGGAGGCGGTCGTGGTTCTCGCTGAGGGGGAATACGAGAGCATGCAGGAAACGCTGCATC
TTTTATCCAACCCGGCAAATGCCTTACGACTTCGTACTTCCATGGATCAACTTGAACGCGGCGATATCATCGAGCGGGAT
CCAACCGAAGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|