Detailed information of TA system TA169908

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 710985..711678
• Replicon: chromosome
• Accession: NZ_CP060083
• Organism: Escherichia coli strain G1/2

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: S1EZG2
• Locus tag: H4P46_RS03415
• Protein ID: WP_000415584.1
• Coordinates: 710985..711281 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: S1EBV2
• Locus tag: H4P46_RS03420
• Protein ID: WP_000650107.1
• Coordinates: 711283..711678 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H4P46_RS03380	706095..706427	+	333	WP_000917684.1	DUF2645 family protein	-
H4P46_RS03385	706473..707822	-	1350	WP_032231458.1	two-component system sensor histidine kinase QseC	-
H4P46_RS03390	707819..708478	-	660	WP_001221493.1	two-component system response regulator QseB	-
H4P46_RS03395	708630..709022	+	393	WP_000712658.1	OB fold stress tolerance protein YgiW	-
H4P46_RS03400	709075..709176	+	102	Protein_666	AraC family transcriptional regulator	-
H4P46_RS03405	709183..710334	-	1152	WP_001254932.1	IS30-like element IS30 family transposase	-
H4P46_RS03410	710394..710780	+	387	Protein_668	GyrI-like domain-containing protein	-
H4P46_RS03415	710985..711281	+	297	WP_000415584.1	type II toxin-antitoxin system toxin MqsR	Toxin
H4P46_RS03420	711283..711678	+	396	WP_000650107.1	type II toxin-antitoxin system antitoxin MqsA	Antitoxin
H4P46_RS03425	711811..713418	+	1608	WP_047644522.1	ABC transporter substrate-binding protein	-
H4P46_RS03430	713556..715814	+	2259	WP_001281881.1	DNA topoisomerase IV subunit A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	709183..710334	1151

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Zinc finger, MqsA-type (3-47)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11231.96 Da
• Isoelectric Point: 8.9070

>T169908 WP_000415584.1 NZ_CP060083:710985-711281 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Nucleotide

• Length: 297 bp

>T169908 NZ_CP076721:1956159-1956497 [Streptococcus parasuis]
ATGGAGAAATATAGAGTCATTATTTCGCCAAAGCTTATTGAGCAAATCAAAAGTATTAGGGATTATGTTGCTAATGTGAA
ACTGAGTCCAGAAACTGCAGAGCGTTTAGTAACGGCCATTTTTGATGAAATAGAGAGCCTAGAACTCTTTCCAGAGCGTG
GATTCGATGCTGATGAAAAAATTGGAGTTAAGATTGATAAGAATGGCCGTAGTAGCCGAGGAATAACCATTCAAAATGGA
AAATATATTGTCATCTATACTGTAAACCAGGAAGAGCATTTAGTTGAAGTTGCTTTCCTATTCTCATCAAAGACTGATTA
TGCTAAACTTTTTAGATAA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14703.10 Da
• Isoelectric Point: 9.2136

>AT169908 WP_000650107.1 NZ_CP060083:711283-711678 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Nucleotide

• Length: 396 bp

>AT169908 NZ_CP076721:1955872-1956159 [Streptococcus parasuis]
ATGCCAACAGTAATAAGGGATAAACAAATCAACTTCAAAGTAAATTCAGAATACTTTGAATTAGCGAAAGTGGTCTTTCA
GGAAAACGGACTGGATATTACATCAGCATTCAATGAATTTGTACAAGAGGTCGCAATTTCCAAAACACTGCCTTTTAAGA
CAGTAGAGGAAAAGGAGAGAGAGAAGTTAATTGCTCGACTTCAAGAAGAAGTTTCCACTAGCTATGAAGCGCTAAAAGCA
GATAAAGGGTTGTCGGTTGAGGAAGCGAGAAAGGCAGTACTAGGATAA

Structures

Toxin

• PDB: 3HI2

Antitoxin

• AlphaFold DB: A0A7U9LU65