Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | DinJ-YafQ (relBE)/YafQ-RelB |
| Location | 3925643..3926184 | Replicon | chromosome |
| Accession | NZ_CP060075 | ||
| Organism | Escherichia coli strain G3/10 | ||
Toxin (Protein)
| Gene name | yafQ | Uniprot ID | A0A0A0F659 |
| Locus tag | H4P47_RS19300 | Protein ID | WP_047400955.1 |
| Coordinates | 3925906..3926184 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | dinJ | Uniprot ID | S1EWQ0 |
| Locus tag | H4P47_RS19295 | Protein ID | WP_000729704.1 |
| Coordinates | 3925643..3925903 (+) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H4P47_RS19270 | 3921426..3922211 | - | 786 | WP_064752182.1 | putative lateral flagellar export/assembly protein LafU | - |
| H4P47_RS19275 | 3922156..3923895 | + | 1740 | WP_047400950.1 | flagellar biosynthesis protein FlhA | - |
| H4P47_RS19280 | 3924000..3924278 | + | 279 | WP_000598760.1 | type II toxin-antitoxin system HicA family toxin | - |
| H4P47_RS19285 | 3924271..3924627 | + | 357 | WP_047400952.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| H4P47_RS19290 | 3924684..3925457 | - | 774 | WP_000543899.1 | C40 family peptidase | - |
| H4P47_RS19295 | 3925643..3925903 | + | 261 | WP_000729704.1 | type II toxin-antitoxin system antitoxin DinJ | Antitoxin |
| H4P47_RS19300 | 3925906..3926184 | + | 279 | WP_047400955.1 | type II toxin-antitoxin system mRNA interferase toxin YafQ | Toxin |
| H4P47_RS19305 | 3926340..3927080 | + | 741 | WP_001225679.1 | murein L,D-transpeptidase | - |
| H4P47_RS19310 | 3927051..3927818 | - | 768 | WP_000333380.1 | class II glutamine amidotransferase | - |
| H4P47_RS19315 | 3928024..3928602 | - | 579 | WP_000284050.1 | D-sedoheptulose 7-phosphate isomerase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10830.62 Da Isoelectric Point: 10.0702
>T169903 WP_047400955.1 NZ_CP060075:3925906-3926184 [Escherichia coli]
MIQRDIEYSGQFSKDVKLTQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG
MIQRDIEYSGQFSKDVKLTQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG
Download Length: 279 bp
>T169903 NZ_CP076721:73202-73969 [Streptococcus parasuis]
ATGAGATTGGAAGAATTTAGTGAGGCTGACTTTCAGAAGGCCTTGCAGCGAACCATTCGAGCCCTAACTCGTGGAAAGAC
AATCCCAGATCAACCAAAAGCTATCTTGCTTGGAGGACAAAGCGGGGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AAGAATTTCAAGGTAATATCATTATCATCGATGGTGATAGCTACCGTTCTCAGCATCCCAATTACTTAGCGCTGAAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTAGTCGATGAACTCAGCAT
GCAAGGCTATCACTTGCTGATTGAGGGAACATTGCGTACCACTCGAGTTCCTCGTCAGACTGCCCAATTATTAGCTTCTA
AAGGTTACCAAGTTTCTTTAGCTGTAATTGGTACCAAACCAGAACTATCCTATCTCAGTACCTTGATTCGTTACGAAGAG
CTTTATGCCATAGATCCGACTCAGGCCAGAGCAACACCAAAGGAACACCATGATGGGATTGTAGAGAACTTGGTGGATAA
CCTAAGGGAGTTAGAAAGCGATAAGATCTTTGACCGCATTCAGATTTATCAAAGAGACAGGACTTGCATTTATGATTCTA
CAATTGATGAAGGCTCCGCAGCAGAAGTGCTACAAGAATGCCTATTTGGAAAATGGAGCAAGGTAGAGGAGGAGATGGTG
AAGGAGAGTGAACTCCTACTTAAGGAATTACTTGAGAAAAATAAATAA
ATGAGATTGGAAGAATTTAGTGAGGCTGACTTTCAGAAGGCCTTGCAGCGAACCATTCGAGCCCTAACTCGTGGAAAGAC
AATCCCAGATCAACCAAAAGCTATCTTGCTTGGAGGACAAAGCGGGGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AAGAATTTCAAGGTAATATCATTATCATCGATGGTGATAGCTACCGTTCTCAGCATCCCAATTACTTAGCGCTGAAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTAGTCGATGAACTCAGCAT
GCAAGGCTATCACTTGCTGATTGAGGGAACATTGCGTACCACTCGAGTTCCTCGTCAGACTGCCCAATTATTAGCTTCTA
AAGGTTACCAAGTTTCTTTAGCTGTAATTGGTACCAAACCAGAACTATCCTATCTCAGTACCTTGATTCGTTACGAAGAG
CTTTATGCCATAGATCCGACTCAGGCCAGAGCAACACCAAAGGAACACCATGATGGGATTGTAGAGAACTTGGTGGATAA
CCTAAGGGAGTTAGAAAGCGATAAGATCTTTGACCGCATTCAGATTTATCAAAGAGACAGGACTTGCATTTATGATTCTA
CAATTGATGAAGGCTCCGCAGCAGAAGTGCTACAAGAATGCCTATTTGGAAAATGGAGCAAGGTAGAGGAGGAGATGGTG
AAGGAGAGTGAACTCCTACTTAAGGAATTACTTGAGAAAAATAAATAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9391.77 Da Isoelectric Point: 5.0758
>AT169903 WP_000729704.1 NZ_CP060075:3925643-3925903 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI
Download Length: 261 bp
>AT169903 NZ_CP076721:72726-73202 [Streptococcus parasuis]
ATGATCGGAGACAATATCAAATCACTACGCCATACACACGATTTGACACAGCCAGAATTTGCGAAAATGTTGGGGATTTC
ACGCAATAGCCTGAGTCGCTATGAAAATGGCACCAGCACCGTATCAACAGAGCTCATCGACCGCATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTTTAGGGGAGGATAAGATGCTAACACCTGTTGAAGATTACCAACTGACTTTAAAAATAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTTTAGATATCAGGATAGTCAAGAAATTGCTTTTGATGATGA
AACAAATCCTTGGATTCTCATGAGTGATGATTTGGCTGAATTGATCCATACGAAAATTTACCTTGTCGATACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGATGGTATTGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGCTTAA
ATGATCGGAGACAATATCAAATCACTACGCCATACACACGATTTGACACAGCCAGAATTTGCGAAAATGTTGGGGATTTC
ACGCAATAGCCTGAGTCGCTATGAAAATGGCACCAGCACCGTATCAACAGAGCTCATCGACCGCATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTTTAGGGGAGGATAAGATGCTAACACCTGTTGAAGATTACCAACTGACTTTAAAAATAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTTTAGATATCAGGATAGTCAAGAAATTGCTTTTGATGATGA
AACAAATCCTTGGATTCTCATGAGTGATGATTTGGCTGAATTGATCCATACGAAAATTTACCTTGTCGATACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGATGGTATTGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0A0F659 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 4ML0 | |
| AlphaFold DB | A0A0E0Y6Z6 |