Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/Tad-HTH_37 |
Location | 2545421..2546048 | Replicon | chromosome |
Accession | NZ_CP060057 | ||
Organism | Escherichia coli strain G8 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A0Q3ID11 |
Locus tag | H4P51_RS12410 | Protein ID | WP_016232083.1 |
Coordinates | 2545719..2546048 (-) | Length | 110 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A0A0H4B4 |
Locus tag | H4P51_RS12405 | Protein ID | WP_047644930.1 |
Coordinates | 2545421..2545729 (-) | Length | 103 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H4P51_RS12365 | 2540527..2540727 | + | 201 | WP_000437871.1 | Cro/Cl family transcriptional regulator | - |
H4P51_RS12370 | 2540866..2541162 | + | 297 | WP_032257057.1 | hypothetical protein | - |
H4P51_RS12375 | 2541326..2542425 | + | 1100 | Protein_2419 | DNA-binding protein | - |
H4P51_RS12380 | 2542432..2543172 | + | 741 | WP_032179071.1 | ATP-binding protein | - |
H4P51_RS12385 | 2543198..2543968 | + | 771 | WP_054518628.1 | DUF1627 domain-containing protein | - |
H4P51_RS12390 | 2543984..2544415 | + | 432 | WP_000196185.1 | DUF977 family protein | - |
H4P51_RS12395 | 2544448..2545122 | - | 675 | WP_032144013.1 | DUF4145 domain-containing protein | - |
H4P51_RS12400 | 2545121..2545366 | + | 246 | WP_001624507.1 | hypothetical protein | - |
H4P51_RS12405 | 2545421..2545729 | - | 309 | WP_047644930.1 | helix-turn-helix transcriptional regulator | Antitoxin |
H4P51_RS12410 | 2545719..2546048 | - | 330 | WP_016232083.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
H4P51_RS12415 | 2546368..2547039 | + | 672 | WP_054518629.1 | ORF6N domain-containing protein | - |
H4P51_RS12420 | 2547094..2547504 | + | 411 | WP_047645478.1 | recombination protein NinB | - |
H4P51_RS12425 | 2547501..2547692 | + | 192 | WP_001254269.1 | NinE family protein | - |
H4P51_RS12430 | 2547716..2548006 | + | 291 | WP_024194163.1 | DUF1364 domain-containing protein | - |
H4P51_RS12435 | 2548003..2548365 | + | 363 | WP_021565206.1 | RusA family crossover junction endodeoxyribonuclease | - |
H4P51_RS12440 | 2548362..2548562 | + | 201 | WP_000994506.1 | protein ninH | - |
H4P51_RS12445 | 2548555..2548797 | + | 243 | WP_001624519.1 | hypothetical protein | - |
H4P51_RS12450 | 2548797..2549411 | + | 615 | WP_001241329.1 | hypothetical protein | - |
H4P51_RS12455 | 2549687..2549980 | - | 294 | WP_159105021.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 2504403..2668333 | 163930 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 110 a.a. Molecular weight: 12732.74 Da Isoelectric Point: 9.2605
>T169795 WP_016232083.1 NZ_CP060057:c2546048-2545719 [Escherichia coli]
MNYIIEYYSDEVEAEILSLPETLQARYIRYTEKMRIYGANLGSPHTEAFGDGLFEIRLKGSEGIGRVFYCTLKGKRIIML
HSFVKKTQKTPPAELRKAETRMKEVKHDW
MNYIIEYYSDEVEAEILSLPETLQARYIRYTEKMRIYGANLGSPHTEAFGDGLFEIRLKGSEGIGRVFYCTLKGKRIIML
HSFVKKTQKTPPAELRKAETRMKEVKHDW
Download Length: 330 bp
>T169795 NZ_CP076694:c26622-26488 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11065.78 Da Isoelectric Point: 9.7256
>AT169795 WP_047644930.1 NZ_CP060057:c2545729-2545421 [Escherichia coli]
MTGKRTPPTMTHDDMVEKMLSNPAVKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGTSG
PSFATLKKFARATGKKLQIRFV
MTGKRTPPTMTHDDMVEKMLSNPAVKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGTSG
PSFATLKKFARATGKKLQIRFV
Download Length: 309 bp
>AT169795 NZ_CP076694:26668-26719 [Escherichia coli]
TCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0Q3ID11 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0A0H4B4 |