Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 256942..257557 | Replicon | chromosome |
| Accession | NZ_CP060047 | ||
| Organism | Vibrio vulnificus strain 2497-87 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMG5 |
| Locus tag | H6S61_RS01335 | Protein ID | WP_001162670.1 |
| Coordinates | 257270..257557 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | H6S61_RS01330 | Protein ID | WP_001232701.1 |
| Coordinates | 256942..257259 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H6S61_RS01290 | 252221..252355 | - | 135 | Protein_258 | DUF3265 domain-containing protein | - |
| H6S61_RS01295 | 252346..252810 | - | 465 | WP_038969901.1 | GNAT family N-acetyltransferase | - |
| H6S61_RS01300 | 252966..253388 | - | 423 | WP_130347440.1 | VOC family protein | - |
| H6S61_RS01305 | 253390..253548 | - | 159 | WP_185892142.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01310 | 254031..254789 | - | 759 | WP_185891251.1 | hypothetical protein | - |
| H6S61_RS01315 | 254967..255335 | - | 369 | WP_088427763.1 | VOC family protein | - |
| H6S61_RS01320 | 255501..256316 | - | 816 | WP_185891253.1 | DUF2726 domain-containing protein | - |
| H6S61_RS01325 | 256316..256465 | - | 150 | WP_185892143.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01330 | 256942..257259 | - | 318 | WP_001232701.1 | HigA family addiction module antidote protein | Antitoxin |
| H6S61_RS01335 | 257270..257557 | - | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| H6S61_RS01340 | 257668..257799 | - | 132 | WP_176721265.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01345 | 257774..257968 | - | 195 | WP_069494789.1 | hypothetical protein | - |
| H6S61_RS01350 | 258820..259062 | + | 243 | WP_011080384.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| H6S61_RS01355 | 259059..259271 | + | 213 | Protein_271 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| H6S61_RS01360 | 259376..260584 | + | 1209 | WP_185890792.1 | IS4 family transposase | - |
| H6S61_RS01365 | 260598..260696 | + | 99 | Protein_273 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| H6S61_RS01370 | 260657..260815 | - | 159 | WP_185892145.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01375 | 261158..261286 | - | 129 | WP_185892147.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01380 | 261293..261703 | - | 411 | WP_185891255.1 | hypothetical protein | - |
| H6S61_RS01385 | 261850..262329 | - | 480 | WP_072609946.1 | peptidase T | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 217740..379394 | 161654 | |
| - | flank | IS/Tn | - | - | 259376..260584 | 1208 | |
| - | inside | Integron | - | - | 221640..379394 | 157754 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11349.95 Da Isoelectric Point: 6.7187
>T169749 WP_001162670.1 NZ_CP060047:c257557-257270 [Vibrio vulnificus]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
Download Length: 288 bp
>T169749 NZ_CP076689:94249-94533 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11705.63 Da Isoelectric Point: 10.4711
>AT169749 WP_001232701.1 NZ_CP060047:c257259-256942 [Vibrio vulnificus]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
Download Length: 318 bp
>AT169749 NZ_CP076689:94013-94246 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|