Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2517674..2518289 Replicon chromosome
Accession NZ_CP060040
Organism Burkholderia cenocepacia strain PS27

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag SY91_RS27660 Protein ID WP_043888217.1
Coordinates 2517948..2518289 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SY91_RS27655 Protein ID WP_012338842.1
Coordinates 2517674..2517961 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SY91_RS27625 2513286..2514107 + 822 WP_023477214.1 SDR family oxidoreductase -
SY91_RS27630 2514196..2514975 - 780 WP_023477215.1 5'/3'-nucleotidase SurE -
SY91_RS27635 2515167..2515475 - 309 WP_023477216.1 AzlD family protein -
SY91_RS27640 2515468..2516202 - 735 WP_023477217.1 AzlC family ABC transporter permease -
SY91_RS27645 2516328..2516786 + 459 WP_006486309.1 Lrp/AsnC family transcriptional regulator -
SY91_RS27650 2517022..2517591 + 570 WP_011548437.1 hypothetical protein -
SY91_RS27655 2517674..2517961 - 288 WP_012338842.1 helix-turn-helix domain-containing protein Antitoxin
SY91_RS27660 2517948..2518289 - 342 WP_043888217.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SY91_RS27665 2518504..2519136 - 633 WP_023477219.1 LysE family translocator -
SY91_RS27670 2519278..2520147 - 870 WP_023477220.1 hypothetical protein -
SY91_RS27675 2520257..2520589 - 333 WP_023477221.1 DUF2322 family protein -
SY91_RS27680 2520643..2520798 - 156 Protein_2211 MFS transporter -
SY91_RS27685 2520797..2521501 - 705 WP_023477223.1 flavin reductase family protein -
SY91_RS27690 2521733..2522059 + 327 WP_006485487.1 thioredoxin family protein -
SY91_RS27695 2522070..2522489 + 420 WP_043888223.1 secondary thiamine-phosphate synthase enzyme YjbQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(20-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-90)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12920.07 Da        Isoelectric Point: 10.2364

>T169743 WP_043888217.1 NZ_CP060040:c2518289-2517948 [Burkholderia cenocepacia]
MPTHGYEIPFFNERVAAGVASLPTTLLARYFALADRMERYGPNLGEPHSQSMGNGLYERRLKGAEGIARVFYCAIVERRI
VMLHCFVKKTPRTPLKELEIARRRLKEVRDGNV

Download         Length: 342 bp

>T169743 NZ_CP076687:c4007111-4007004 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10394.94 Da        Isoelectric Point: 9.6538

>AT169743 WP_012338842.1 NZ_CP060040:c2517961-2517674 [Burkholderia cenocepacia]
MATYKELRERALADPAVRTEYERLNREEFALLDAMLAARREAGLSQADVAARMGTKAPAITRLERALATGQHSPSVDTLR
KYAAACGKTLVISFA

Download         Length: 288 bp

>AT169743 NZ_CP076687:4007160-4007225 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References