Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3767047..3767773 Replicon chromosome
Accession NZ_CP059997
Organism Amycolatopsis sp. CA-230715

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HUW46_RS17675 Protein ID WP_215548311.1
Coordinates 3767402..3767773 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HUW46_RS17670 Protein ID WP_215548310.1
Coordinates 3767047..3767409 (-) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW46_RS48355 3762825..3763136 - 312 WP_254126283.1 hypothetical protein -
HUW46_RS17650 (HUW46_03492) 3764101..3764463 + 363 WP_215548306.1 hypothetical protein -
HUW46_RS17655 (HUW46_03493) 3764949..3765749 + 801 WP_215548307.1 alpha/beta hydrolase -
HUW46_RS17660 (HUW46_03494) 3765760..3766455 + 696 WP_215548308.1 DUF5710 domain-containing protein -
HUW46_RS17665 (HUW46_03495) 3766458..3766988 - 531 WP_215548309.1 hypothetical protein -
HUW46_RS17670 (HUW46_03496) 3767047..3767409 - 363 WP_215548310.1 XRE family transcriptional regulator Antitoxin
HUW46_RS17675 (HUW46_03497) 3767402..3767773 - 372 WP_215548311.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUW46_RS17690 (HUW46_03500) 3768184..3769896 - 1713 WP_215548312.1 phosphatidylglycerol lysyltransferase domain-containing protein -
HUW46_RS17695 (HUW46_03501) 3769941..3771926 - 1986 WP_215548313.1 acetoacetate--CoA ligase -
HUW46_RS17700 (HUW46_03502) 3771945..3772574 - 630 WP_215548314.1 dienelactone hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(22-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-91)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13861.65 Da        Isoelectric Point: 4.5971

>T169662 WP_215548311.1 NZ_CP059997:c3767773-3767402 [Amycolatopsis sp. CA-230715]
MAWEIQLHPEVTAWFLELVQEDPDSADLVEHAIDLLAEEGPSLGRPLADRIKGSRIHNMKELRPASTGTSEVRILFVFDP
RRCAALLVAGNKEGQWEKWYRKAIPLAEERYEAHTAAAEVDDG

Download         Length: 372 bp

>T169662 NZ_CP076652:c5676007-5675825 [Pseudomonas savastanoi]
ATGAAATGCAACGAGTTTCGGCGATGGTTGCAGGCTCAAGGCGCTGAGTTCAGGGCGGCCAAGGGTAGTCATTTCAAGGT
TTACCTGAATGGTAAGGCAACCATCTTTGCAGACCATGGCAGCAAAGAAATGCACGAAGGGTTACGCAAGTCGATCATCA
AGCAGCTCGGCCTTAAGGATTGA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13402.02 Da        Isoelectric Point: 5.8002

>AT169662 WP_215548310.1 NZ_CP059997:c3767409-3767047 [Amycolatopsis sp. CA-230715]
MADWKDVKARKREIDQEADRDLQAARSEASARTHAYVLGYRLSELRERVGLSQTQVAERMGVKQPRVSAIEKGDPAQMEV
ETLQRYIAALGGRLRVVAGFGDHEEIVSISAVDRDEYASA

Download         Length: 363 bp

>AT169662 NZ_CP076652:c5675793-5675368 [Pseudomonas savastanoi]
ATGTATCAATATCCATTGGATCTGCATCGGGAGCCGACAGGCGTTTGGCTTTCGTGTCCAGACATTCCCGAAATGAGCGC
CTCTGGCGACACCCTGCCTGAAGCATTGAGCGAAGCTCTTGACGGCATGGAATCGGCTCTATCGCTCTACGTCGATCAAC
GTCGCAAGATTCCCCAGGCCTCAGTCGTACCCGGCCATGAACTGTTGATGCGTTTGCCTGCGCTGACTGTTGCCAAAATC
ATGCTATGGAACAGCTTGTTGGAAGAGGGCGTTAGCCGTGCTGAGCTGGCGCGTCGCCTGGGTTGTACGCGGCAAGTGGT
GGATCGGCTTGTGGACTTTCTGCATGCCTCGAAAATCGAGCAGGTGGAGCGAGCGCTGGCTGAGCTTGGCCGGCGTATTA
CGTTGAGCATTGAGCGGACCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References