Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2731237..2731736 Replicon chromosome
Accession NZ_CP059997
Organism Amycolatopsis sp. CA-230715

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag HUW46_RS12540 Protein ID WP_215547446.1
Coordinates 2731476..2731736 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag HUW46_RS12535 Protein ID WP_254126594.1
Coordinates 2731237..2731479 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW46_RS12520 (HUW46_02470) 2726457..2727110 + 654 WP_215547442.1 LppX_LprAFG lipoprotein -
HUW46_RS12525 (HUW46_02471) 2727117..2728661 - 1545 WP_215547443.1 alpha/beta hydrolase -
HUW46_RS12530 (HUW46_02472) 2728836..2731169 + 2334 WP_215547444.1 accessory Sec system translocase SecA2 -
HUW46_RS12535 (HUW46_02473) 2731237..2731479 + 243 WP_254126594.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HUW46_RS12540 (HUW46_02474) 2731476..2731736 + 261 WP_215547446.1 Txe/YoeB family addiction module toxin Toxin
HUW46_RS12545 (HUW46_02475) 2731753..2732643 - 891 WP_215547447.1 LysR family transcriptional regulator -
HUW46_RS12550 (HUW46_02476) 2732718..2733629 + 912 WP_215547448.1 DMT family transporter -
HUW46_RS12555 (HUW46_02477) 2733676..2735391 + 1716 WP_215547449.1 NAD+ synthase -
HUW46_RS12560 (HUW46_02478) 2735670..2736326 - 657 WP_215547450.1 DUF4386 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10433.92 Da        Isoelectric Point: 9.9394

>T169661 WP_215547446.1 NZ_CP059997:2731476-2731736 [Amycolatopsis sp. CA-230715]
MKLVWDAFAWDDYLWRQTQDRKVLKRINDLLKDVRRNGNEGIGKPEPLKHGFQGYWSRRITDEHRLVYKIEGDEIRIAAC
RYHYGK

Download         Length: 261 bp

>T169661 NZ_CP076652:c4411134-4410952 [Pseudomonas savastanoi]
GTGCAGAGCAGGCAATTGATAAAGGAGCTTGAAGCAGATGGATGGATTCTGGATCGTGTTTCAGGCAGTCACCATATGTT
CAAGCATCCTGAAAAACTTCAGACAGTCCCCGTGCCGCATCCCAAGAAAGACTTGCCATTCGGAACGGTGCGGGCCATCA
AAAAGCTTGCCGGGCTGGTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8937.78 Da        Isoelectric Point: 4.2176

>AT169661 WP_254126594.1 NZ_CP059997:2731237-2731479 [Amycolatopsis sp. CA-230715]
MSYSESRANYAETLDSVVNDREEVVITRAGHDPVVIVSLDDYESLKETAYLLRSPENARRLVSAIERLESGGGEQHELAE

Download         Length: 243 bp

>AT169661 NZ_CP076652:c4410916-4410512 [Pseudomonas savastanoi]
ATGAAATATCCAATGTGCATAGAATGGGGAAGCGAAACCACGGCGTTTGGTATCCAGATTCCCGATATCCCAGGTGCCGT
AACCGCAGGCGATACGTTCGAGGAAGCCCACGCCGCGGCGGTGGAGATTGCTCATATCATGCTTCAGGAAATAGCAGCTG
GTGGTGGAACCATACCCAAGGCCGGCACTGTTGCCGAGCACGCCAGGAATGCCGATTTCGCCGGAATGGGCTGGGGCATG
ATCGAGATTGACGTAACGCCTTATCTTGGTAAGACGGAGAAGGTCAACGTCACACTGCCTGGTTTCGTGATCAAGCAGAT
CGATCGCTATGTACGGGATCACAGCATCAAGAGTCGTTCCACCTTCCTGGCCGACGCGGCGCTGGAAAAACTGGGCCGGG
CATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References