Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2273203..2274554 Replicon chromosome
Accession NZ_CP059958
Organism Pectobacterium brasiliense strain IPO:4065 NAK:223

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag H5A29_RS10045 Protein ID WP_119871557.1
Coordinates 2273514..2274554 (+) Length 347 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A086EBR8
Locus tag H5A29_RS10040 Protein ID WP_039279922.1
Coordinates 2273203..2273517 (+) Length 105 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5A29_RS10015 2269000..2270034 + 1035 WP_119871561.1 putative FMN-dependent luciferase-like monooxygenase -
H5A29_RS10020 2270031..2271164 + 1134 WP_119871560.1 alkylhydroperoxidase domain protein -
H5A29_RS10025 2271221..2271733 - 513 WP_185893742.1 phenolic acid decarboxylase -
H5A29_RS10030 2271833..2272705 + 873 WP_119871558.1 LysR family transcriptional regulator -
H5A29_RS10035 2272892..2273218 + 327 WP_039510297.1 helix-turn-helix domain-containing protein -
H5A29_RS10040 2273203..2273517 + 315 WP_039279922.1 HipA N-terminal domain-containing protein Antitoxin
H5A29_RS10045 2273514..2274554 + 1041 WP_119871557.1 HipA domain-containing protein Toxin
H5A29_RS10050 2274614..2275237 - 624 WP_119871556.1 LysE family translocator -
H5A29_RS10055 2275505..2276260 + 756 WP_119871555.1 thiol:disulfide interchange protein DsbG -
H5A29_RS10060 2276294..2277199 - 906 WP_119871554.1 siderophore-interacting protein -
H5A29_RS10065 2277454..2277705 + 252 WP_010281712.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
H5A29_RS10070 2277702..2277989 + 288 WP_015842269.1 type II toxin-antitoxin system RelE/ParE family toxin -
H5A29_RS10075 2278107..2279459 - 1353 WP_119871553.1 glutathione-disulfide reductase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(57-307)

Antitoxin

(5-98)


Sequences


Toxin        


Download         Length: 347 a.a.        Molecular weight: 39677.65 Da        Isoelectric Point: 6.4479

>T169550 WP_119871557.1 NZ_CP059958:2273514-2274554 [Pectobacterium brasiliense]
MTRCRILLTPLTHEEEIATGYSRKGLKHLAGKMHTSPDLRFTRQQFMHDLPQAQKGMSISGYQPKIQLVLEEQAFTVVDH
QGLYILKHSPIEFPYLAENEHATMTLMARLGFAVPPHGLLRFKPEQADDEPEFAFVIKRFDRDEKTGHPIHQEQLDGAMG
IGEKFGKTHTDGRQYVSYERLALFLSKHVNDNIVFKIDLFRRIAYAYMLGNNDMHLRNFGLMHLRSGQLMLAPIYDFVSV
APYPTYFSSCFMALPLLIQEEGDEALAPGFETAYGEYLGMDFILFGQRIGLSENLTKKLLADLTKEAECVETTYRDSFMP
ADAIETTLRCYRHRLNLMSILDAERI

Download         Length: 1041 bp

>T169550 NZ_CP076591:c1746222-1745803 [Erwinia amylovora]
GTGGTCCTGTGGCAATGTGAACTGCGGCCATCAAGGCTGGCACAGCGGTTTTCGCTGCTGCTGCATGGGGCAGTGATGCT
GGCGCTGCTATTGCCGACATGGCCCGCCAGCTCTGGCCTGGTGCGGATGCTGTTGCTGGTTTTGGTACTGTTGGAGTGCA
TACGCAGTCGGCGGCGCATTGGTCGTCGCCAGGGGGATATCGCTCTGTTGGAAGGGCATGAGCTACGCTGGCGTCAACGC
GAGTGGTGCATTATTTCCCGTCCGTGGCTGACCGGGCAGGCAATCCTGCTGTTACTACAGGATACTCATGGACAGCGCGA
GCGACTATGGCTGTTCGCCGACGGCATGGAAAAACGTAACTGGCGTCAGCTGCGCCTGCAATTGCTGAACAGTAAAGTAC
AGGGGAATGGCTGGTGCTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11898.74 Da        Isoelectric Point: 9.8041

>AT169550 WP_039279922.1 NZ_CP059958:2273203-2273517 [Pectobacterium brasiliense]
MRRQVKVYLYGVHIGQLSQDDKGYLFEYKKSYIGPPLSLSLPIQTGTFRSRTLPPYFASLAPEGWLRRQYSQLQHLDEKD
LFGILIQNGKNLIGAVQLIAEDKA

Download         Length: 315 bp

>AT169550 NZ_CP076591:c1746469-1746203 [Erwinia amylovora]
ATGGATATTACAAATAAATCACGTATTCACTGGGCATGCCGTCGCGGCATGCGCGAGCTGGATATCTCGATCATGCCCTT
TTTCCAGTATGAATTTGACTCGCTGAACGACAGCGATAAACGGCTGTTCGTTCGCCTGCTGGAGAGCGATGACCCGGACC
TGTTCAACTGGCTGATGAACCACGGCGAGCCGGCAGACGTGGAGCTGAAAAGGATGGTGGCGCTAATCCAACAAAGAAAT
AAACAACGTGGTCCTGTGGCAATGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A086EBR8

References