Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | HipBST/HipA(toxin) |
| Location | 2273203..2274554 | Replicon | chromosome |
| Accession | NZ_CP059958 | ||
| Organism | Pectobacterium brasiliense strain IPO:4065 NAK:223 | ||
Toxin (Protein)
| Gene name | HipT | Uniprot ID | - |
| Locus tag | H5A29_RS10045 | Protein ID | WP_119871557.1 |
| Coordinates | 2273514..2274554 (+) | Length | 347 a.a. |
Antitoxin (Protein)
| Gene name | HipS | Uniprot ID | A0A086EBR8 |
| Locus tag | H5A29_RS10040 | Protein ID | WP_039279922.1 |
| Coordinates | 2273203..2273517 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H5A29_RS10015 | 2269000..2270034 | + | 1035 | WP_119871561.1 | putative FMN-dependent luciferase-like monooxygenase | - |
| H5A29_RS10020 | 2270031..2271164 | + | 1134 | WP_119871560.1 | alkylhydroperoxidase domain protein | - |
| H5A29_RS10025 | 2271221..2271733 | - | 513 | WP_185893742.1 | phenolic acid decarboxylase | - |
| H5A29_RS10030 | 2271833..2272705 | + | 873 | WP_119871558.1 | LysR family transcriptional regulator | - |
| H5A29_RS10035 | 2272892..2273218 | + | 327 | WP_039510297.1 | helix-turn-helix domain-containing protein | - |
| H5A29_RS10040 | 2273203..2273517 | + | 315 | WP_039279922.1 | HipA N-terminal domain-containing protein | Antitoxin |
| H5A29_RS10045 | 2273514..2274554 | + | 1041 | WP_119871557.1 | HipA domain-containing protein | Toxin |
| H5A29_RS10050 | 2274614..2275237 | - | 624 | WP_119871556.1 | LysE family translocator | - |
| H5A29_RS10055 | 2275505..2276260 | + | 756 | WP_119871555.1 | thiol:disulfide interchange protein DsbG | - |
| H5A29_RS10060 | 2276294..2277199 | - | 906 | WP_119871554.1 | siderophore-interacting protein | - |
| H5A29_RS10065 | 2277454..2277705 | + | 252 | WP_010281712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| H5A29_RS10070 | 2277702..2277989 | + | 288 | WP_015842269.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| H5A29_RS10075 | 2278107..2279459 | - | 1353 | WP_119871553.1 | glutathione-disulfide reductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 347 a.a. Molecular weight: 39677.65 Da Isoelectric Point: 6.4479
>T169550 WP_119871557.1 NZ_CP059958:2273514-2274554 [Pectobacterium brasiliense]
MTRCRILLTPLTHEEEIATGYSRKGLKHLAGKMHTSPDLRFTRQQFMHDLPQAQKGMSISGYQPKIQLVLEEQAFTVVDH
QGLYILKHSPIEFPYLAENEHATMTLMARLGFAVPPHGLLRFKPEQADDEPEFAFVIKRFDRDEKTGHPIHQEQLDGAMG
IGEKFGKTHTDGRQYVSYERLALFLSKHVNDNIVFKIDLFRRIAYAYMLGNNDMHLRNFGLMHLRSGQLMLAPIYDFVSV
APYPTYFSSCFMALPLLIQEEGDEALAPGFETAYGEYLGMDFILFGQRIGLSENLTKKLLADLTKEAECVETTYRDSFMP
ADAIETTLRCYRHRLNLMSILDAERI
MTRCRILLTPLTHEEEIATGYSRKGLKHLAGKMHTSPDLRFTRQQFMHDLPQAQKGMSISGYQPKIQLVLEEQAFTVVDH
QGLYILKHSPIEFPYLAENEHATMTLMARLGFAVPPHGLLRFKPEQADDEPEFAFVIKRFDRDEKTGHPIHQEQLDGAMG
IGEKFGKTHTDGRQYVSYERLALFLSKHVNDNIVFKIDLFRRIAYAYMLGNNDMHLRNFGLMHLRSGQLMLAPIYDFVSV
APYPTYFSSCFMALPLLIQEEGDEALAPGFETAYGEYLGMDFILFGQRIGLSENLTKKLLADLTKEAECVETTYRDSFMP
ADAIETTLRCYRHRLNLMSILDAERI
Download Length: 1041 bp
>T169550 NZ_CP076591:c1746222-1745803 [Erwinia amylovora]
GTGGTCCTGTGGCAATGTGAACTGCGGCCATCAAGGCTGGCACAGCGGTTTTCGCTGCTGCTGCATGGGGCAGTGATGCT
GGCGCTGCTATTGCCGACATGGCCCGCCAGCTCTGGCCTGGTGCGGATGCTGTTGCTGGTTTTGGTACTGTTGGAGTGCA
TACGCAGTCGGCGGCGCATTGGTCGTCGCCAGGGGGATATCGCTCTGTTGGAAGGGCATGAGCTACGCTGGCGTCAACGC
GAGTGGTGCATTATTTCCCGTCCGTGGCTGACCGGGCAGGCAATCCTGCTGTTACTACAGGATACTCATGGACAGCGCGA
GCGACTATGGCTGTTCGCCGACGGCATGGAAAAACGTAACTGGCGTCAGCTGCGCCTGCAATTGCTGAACAGTAAAGTAC
AGGGGAATGGCTGGTGCTAA
GTGGTCCTGTGGCAATGTGAACTGCGGCCATCAAGGCTGGCACAGCGGTTTTCGCTGCTGCTGCATGGGGCAGTGATGCT
GGCGCTGCTATTGCCGACATGGCCCGCCAGCTCTGGCCTGGTGCGGATGCTGTTGCTGGTTTTGGTACTGTTGGAGTGCA
TACGCAGTCGGCGGCGCATTGGTCGTCGCCAGGGGGATATCGCTCTGTTGGAAGGGCATGAGCTACGCTGGCGTCAACGC
GAGTGGTGCATTATTTCCCGTCCGTGGCTGACCGGGCAGGCAATCCTGCTGTTACTACAGGATACTCATGGACAGCGCGA
GCGACTATGGCTGTTCGCCGACGGCATGGAAAAACGTAACTGGCGTCAGCTGCGCCTGCAATTGCTGAACAGTAAAGTAC
AGGGGAATGGCTGGTGCTAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11898.74 Da Isoelectric Point: 9.8041
>AT169550 WP_039279922.1 NZ_CP059958:2273203-2273517 [Pectobacterium brasiliense]
MRRQVKVYLYGVHIGQLSQDDKGYLFEYKKSYIGPPLSLSLPIQTGTFRSRTLPPYFASLAPEGWLRRQYSQLQHLDEKD
LFGILIQNGKNLIGAVQLIAEDKA
MRRQVKVYLYGVHIGQLSQDDKGYLFEYKKSYIGPPLSLSLPIQTGTFRSRTLPPYFASLAPEGWLRRQYSQLQHLDEKD
LFGILIQNGKNLIGAVQLIAEDKA
Download Length: 315 bp
>AT169550 NZ_CP076591:c1746469-1746203 [Erwinia amylovora]
ATGGATATTACAAATAAATCACGTATTCACTGGGCATGCCGTCGCGGCATGCGCGAGCTGGATATCTCGATCATGCCCTT
TTTCCAGTATGAATTTGACTCGCTGAACGACAGCGATAAACGGCTGTTCGTTCGCCTGCTGGAGAGCGATGACCCGGACC
TGTTCAACTGGCTGATGAACCACGGCGAGCCGGCAGACGTGGAGCTGAAAAGGATGGTGGCGCTAATCCAACAAAGAAAT
AAACAACGTGGTCCTGTGGCAATGTGA
ATGGATATTACAAATAAATCACGTATTCACTGGGCATGCCGTCGCGGCATGCGCGAGCTGGATATCTCGATCATGCCCTT
TTTCCAGTATGAATTTGACTCGCTGAACGACAGCGATAAACGGCTGTTCGTTCGCCTGCTGGAGAGCGATGACCCGGACC
TGTTCAACTGGCTGATGAACCACGGCGAGCCGGCAGACGTGGAGCTGAAAAGGATGGTGGCGCTAATCCAACAAAGAAAT
AAACAACGTGGTCCTGTGGCAATGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|