Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 742508..743180 Replicon chromosome
Accession NZ_CP059957
Organism Pectobacterium brasiliense strain IPO:4071 NAK:240

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H5A30_RS03435 Protein ID WP_119870773.1
Coordinates 742794..743180 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A433N287
Locus tag H5A30_RS03430 Protein ID WP_010281167.1
Coordinates 742508..742807 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5A30_RS03410 737773..738750 + 978 WP_119870771.1 nucleoside hydrolase -
H5A30_RS03415 738750..739727 + 978 WP_010296900.1 ABC transporter permease -
H5A30_RS03420 739724..740632 + 909 WP_039275990.1 ABC transporter permease -
H5A30_RS03425 740672..742471 + 1800 WP_119870772.1 ABC transporter ATP-binding protein -
H5A30_RS03430 742508..742807 - 300 WP_010281167.1 XRE family transcriptional regulator Antitoxin
H5A30_RS03435 742794..743180 - 387 WP_119870773.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H5A30_RS03440 743502..744200 + 699 WP_005976717.1 D-galactonate utilization transcriptional regulator DgoR -
H5A30_RS03445 744197..745093 + 897 WP_119870774.1 2-dehydro-3-deoxygalactonokinase -
H5A30_RS03450 745077..745694 + 618 WP_010281152.1 2-dehydro-3-deoxy-6-phosphogalactonate aldolase -
H5A30_RS03455 745691..746839 + 1149 WP_010281150.1 galactonate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14718.77 Da        Isoelectric Point: 5.0357

>T169531 WP_119870773.1 NZ_CP059957:c743180-742794 [Pectobacterium brasiliense]
MEVYRLAWEIVTRALFDTWFDEQTETVQEEVLAHLAILEEDGPQLGRPQVDQIKGSKYKNMKELRVQVGGHPFRTFFAFD
RTRKAIVLCAGDKKGENAKLFYERMIKIADAEFASHLISPEVKEDGDA

Download         Length: 387 bp

>T169531 NZ_CP076554:122694-122843 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11048.08 Da        Isoelectric Point: 10.6442

>AT169531 WP_010281167.1 NZ_CP059957:c742807-742508 [Pectobacterium brasiliense]
MATLKEMMAKRSPESRARIEARTAEIRQEITLAKLREELNMSQTQLALALGVKQPSIVKMEKVENDPKLSTLKRYVTALG
GKLTLDVTLPDGKRIALTL

Download         Length: 300 bp

>AT169531 NZ_CP076554:c122649-122590 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A433N287

References