Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3048860..3049520 Replicon chromosome
Accession NZ_CP059956
Organism Pectobacterium brasiliense strain IPO:4132 NAK:239

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H5A38_RS13635 Protein ID WP_180788117.1
Coordinates 3049167..3049520 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H5A38_RS13630 Protein ID WP_010284412.1
Coordinates 3048860..3049162 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5A38_RS13605 3043982..3045418 - 1437 WP_205547605.1 family 1 glycosylhydrolase -
H5A38_RS13610 3045622..3046077 - 456 WP_014914860.1 helix-turn-helix domain-containing protein -
H5A38_RS13615 3046144..3047403 + 1260 WP_205547602.1 MFS transporter -
H5A38_RS13620 3047415..3047765 - 351 WP_205547599.1 helix-turn-helix domain-containing protein -
H5A38_RS13625 3047818..3048822 + 1005 WP_205547596.1 pyridoxal-phosphate dependent enzyme -
H5A38_RS13630 3048860..3049162 - 303 WP_010284412.1 helix-turn-helix domain-containing protein Antitoxin
H5A38_RS13635 3049167..3049520 - 354 WP_180788117.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H5A38_RS13640 3049744..3050184 - 441 WP_039500392.1 helix-turn-helix transcriptional regulator -
H5A38_RS13645 3050287..3050898 + 612 WP_205547594.1 NAD(P)H-binding protein -
H5A38_RS13650 3051063..3051902 + 840 WP_205546283.1 glutathione-dependent disulfide-bond oxidoreductase -
H5A38_RS13655 3051962..3053206 - 1245 WP_205546282.1 Bcr/CflA family efflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13620.76 Da        Isoelectric Point: 10.0708

>T169517 WP_180788117.1 NZ_CP059956:c3049520-3049167 [Pectobacterium brasiliense]
VWKIEMTDVFDSWFSTLNDRDRAYVLAALIVLREKGPMLSRPYADTVKGSRYFNMKELRIQSGGMPIRAFFAFDPHRTGI
LLCAGNKSGNEKRFYDEMIPLADREFTKYLKKSEKRG

Download         Length: 354 bp

>T169517 NZ_CP076532:528234-528584 [Bacillus sp. JNUCC-24]
TTGATTGTTAAACGCGGTGATGTTTACTTTGCTGATTTATCTCCTGTTGTTGGCTCCGAGCAGGGCGGGGTTCGCCCAGT
ATTGGTGATTCAAAATGACATTGGAAATCGCTTCAGCCCGACTGCTATCGTTGCAGCCATAACAGCCCAAATACAAAAAG
CGAAATTACCGACTCACGTCGAAATTGATGCAAAGCGCTACGGCTTTGAGCGAGATTCTGTCATTCTCTTGGAGCAGATT
CGTACAATCGATAAACAAAGATTGACAGATAAAATCACACATCTTGATGATGAGATGATGGAGAAGGTTGATGAAGCCTT
ACAAGTTAGTTTGGCTCTTATTGATTTTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11107.90 Da        Isoelectric Point: 6.2283

>AT169517 WP_010284412.1 NZ_CP059956:c3049162-3048860 [Pectobacterium brasiliense]
MGRTLEQLLADEKPDVVVEAHAIAADMLLNIHLAELRERVQKTQVEMAQVLGLKQPTIAGMEKPGRDLKLSTLKRYVEAT
GSKLRLDVELPDGSHYGFTL

Download         Length: 303 bp

>AT169517 NZ_CP076532:527948-528229 [Bacillus sp. JNUCC-24]
TTGTCTGAATCCAGCGCAACAAACGAAATGAAGATTCGACTACCGGAGGCTTTGATGTCTGAAATCGAACGAGTAGCAGA
GCAGGATAAGGTAACAAGAAATGAATTGATCTACCGAGCGACAAAAACGTATATTCGTGAACGTAATATTCGACAAAATC
GTGAATCGATGAGACGCGGCTACATGGAGATGGCGAAAATTAATCTGAATATCTCTTCAGAGGCACAATACGCAGAATTT
GAGGCTGAGAATACAGTTGAGCGATTAGTCAGCGGGGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References