Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1230309..1230981 Replicon chromosome
Accession NZ_CP059955
Organism Pectobacterium brasiliense strain IPO:4134 NAK:395

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H5A16_RS05515 Protein ID WP_119870773.1
Coordinates 1230309..1230695 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A433N287
Locus tag H5A16_RS05520 Protein ID WP_010281167.1
Coordinates 1230682..1230981 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5A16_RS05495 1226650..1227798 - 1149 WP_010281150.1 galactonate dehydratase -
H5A16_RS05500 1227795..1228412 - 618 WP_010281152.1 2-dehydro-3-deoxy-6-phosphogalactonate aldolase -
H5A16_RS05505 1228396..1229292 - 897 WP_119870774.1 2-dehydro-3-deoxygalactonokinase -
H5A16_RS05510 1229289..1229987 - 699 WP_005976717.1 D-galactonate utilization transcriptional regulator DgoR -
H5A16_RS05515 1230309..1230695 + 387 WP_119870773.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H5A16_RS05520 1230682..1230981 + 300 WP_010281167.1 XRE family transcriptional regulator Antitoxin
H5A16_RS05525 1231018..1232817 - 1800 WP_119870772.1 ABC transporter ATP-binding protein -
H5A16_RS05530 1232857..1233765 - 909 WP_039275990.1 ABC transporter permease -
H5A16_RS05535 1233762..1234739 - 978 WP_010296900.1 ABC transporter permease -
H5A16_RS05540 1234739..1235716 - 978 WP_119870771.1 nucleoside hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14718.77 Da        Isoelectric Point: 5.0357

>T169499 WP_119870773.1 NZ_CP059955:1230309-1230695 [Pectobacterium brasiliense]
MEVYRLAWEIVTRALFDTWFDEQTETVQEEVLAHLAILEEDGPQLGRPQVDQIKGSKYKNMKELRVQVGGHPFRTFFAFD
RTRKAIVLCAGDKKGENAKLFYERMIKIADAEFASHLISPEVKEDGDA

Download         Length: 387 bp

>T169499 NZ_CP076527:920329-920436 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11048.08 Da        Isoelectric Point: 10.6442

>AT169499 WP_010281167.1 NZ_CP059955:1230682-1230981 [Pectobacterium brasiliense]
MATLKEMMAKRSPESRARIEARTAEIRQEITLAKLREELNMSQTQLALALGVKQPSIVKMEKVENDPKLSTLKRYVTALG
GKLTLDVTLPDGKRIALTL

Download         Length: 300 bp

>AT169499 NZ_CP076527:c920282-920216 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A433N287

References