Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1826792..1827294 Replicon chromosome
Accession NZ_CP059947
Organism Escherichia coli strain 268.2

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag H5C70_RS08710 Protein ID WP_000767829.1
Coordinates 1827040..1827294 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag H5C70_RS08705 Protein ID WP_094315768.1
Coordinates 1826792..1827043 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5C70_RS08680 1821969..1823036 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
H5C70_RS08685 1823036..1824106 - 1071 WP_094315765.1 histidinol-phosphate transaminase -
H5C70_RS08690 1824103..1825407 - 1305 WP_094315766.1 histidinol dehydrogenase -
H5C70_RS08695 1825413..1826312 - 900 WP_094315767.1 ATP phosphoribosyltransferase -
H5C70_RS08700 1826458..1826508 - 51 WP_001364200.1 his operon leader peptide -
H5C70_RS08705 1826792..1827043 + 252 WP_094315768.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
H5C70_RS08710 1827040..1827294 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
H5C70_RS08715 1827377..1828201 + 825 WP_000754737.1 SDR family oxidoreductase -
H5C70_RS08720 1828247..1829176 + 930 WP_000803366.1 LysR family transcriptional regulator -
H5C70_RS08725 1829391..1829453 + 63 WP_010723108.1 membrane protein YoeI -
H5C70_RS08730 1829443..1830801 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
H5C70_RS08735 1830980..1832038 + 1059 WP_000492321.1 transport protein YeeE -
H5C70_RS08740 1832052..1832279 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T169461 WP_000767829.1 NZ_CP059947:1827040-1827294 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T169461 NZ_CP076494:105236-105382 [Enterococcus faecalis]
ATGAACGTACTTCCAAAATCTATAGAAAGGAGAAGCCTTTTGTCCGTTTCGGAAAGTTTGCAACTAATGCTTGCGTTTGG
TGGGTTTACATTGACCCTAATCACAACCATTGTTGCCATTCTGAACTATAAAGACAAAAAGAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.62 Da        Isoelectric Point: 4.7954

>AT169461 WP_094315768.1 NZ_CP059947:1826792-1827043 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLMRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT169461 NZ_CP076494:c105572-105316 [Enterococcus faecalis]
CACCGCCACCGCCGTTTAGGCGCGCATGAAAAAAGGTAGGCATTCGCCTACCTTTTCGCACAAAATGTGGTATAATAATT
ATGTAAAGAGGACGTACTGGTAATACGCCCTCATTGATAGCACCGCTAAAGACGGTGGCAGAGTTTTTATAAGTTATTTA
GAAATAACCGGTCTCCTGCTAAAGTGACGGTTATTTCTTTTTGTCTTTATAGTTCAGAATGGCAACAATGGTTGTGATTA
GGGTCAATGTAAACCCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure

References