Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3207375..3208068 Replicon chromosome
Accession NZ_CP059929
Organism Escherichia coli strain 162.2

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag H5C75_RS15665 Protein ID WP_000415584.1
Coordinates 3207375..3207671 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag H5C75_RS15670 Protein ID WP_000650107.1
Coordinates 3207673..3208068 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5C75_RS15630 (3202463) 3202463..3202777 - 315 WP_000958598.1 putative quinol monooxygenase -
H5C75_RS15635 (3202808) 3202808..3203388 - 581 Protein_3054 NADPH:quinone oxidoreductase MdaB -
H5C75_RS15640 (3203707) 3203707..3204040 + 334 Protein_3055 DUF2645 family protein -
H5C75_RS15645 (3204086) 3204086..3205435 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
H5C75_RS15650 (3205432) 3205432..3206091 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
H5C75_RS15655 (3206243) 3206243..3206635 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
H5C75_RS15660 (3206688) 3206688..3207170 + 483 WP_000183505.1 GyrI-like domain-containing protein -
H5C75_RS15665 (3207375) 3207375..3207671 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
H5C75_RS15670 (3207673) 3207673..3208068 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
H5C75_RS15675 (3208201) 3208201..3209808 + 1608 WP_032202400.1 ABC transporter substrate-binding protein -
H5C75_RS15680 (3209946) 3209946..3212204 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T169440 WP_000415584.1 NZ_CP059929:3207375-3207671 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T169440 NZ_CP076488:579973-580074 [Enterococcus faecalis]
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAACCCTTGTTGCGTTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT169440 WP_000650107.1 NZ_CP059929:3207673-3208068 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT169440 NZ_CP076488:c580198-580011 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAACGCAACAAGGGTTGCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References