Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 4620945..4621167 Replicon chromosome
Accession NZ_CP059917
Organism Escherichia coli strain 64.1

Toxin (Protein)


Gene name ldrD Uniprot ID A0A829L523
Locus tag H5C78_RS22235 Protein ID WP_000170738.1
Coordinates 4620945..4621052 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 4621101..4621167 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5C78_RS22205 4616831..4617022 + 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
H5C78_RS22210 4617019..4618698 + 1680 WP_001562264.1 cellulose biosynthesis protein BcsG -
H5C78_RS22215 4618813..4619271 - 459 WP_000526135.1 IS200/IS605 family transposase -
H5C78_RS22220 4619496..4619603 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
H5C78_RS22225 4619979..4620086 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
H5C78_RS22230 4620462..4620569 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
H5C78_RS22235 4620945..4621052 - 108 WP_000170738.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- 4621101..4621167 + 67 - - Antitoxin
H5C78_RS22240 4621528..4622799 + 1272 WP_001318103.1 amino acid permease -
H5C78_RS22245 4622829..4623833 - 1005 WP_000107036.1 dipeptide ABC transporter ATP-binding subunit DppF -
H5C78_RS22250 4623830..4624813 - 984 WP_001196486.1 dipeptide ABC transporter ATP-binding protein -
H5C78_RS22255 4624824..4625726 - 903 WP_000084677.1 dipeptide ABC transporter permease DppC -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4618813..4619271 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-35)


Sequences


Toxin        


Download         Length: 36 a.a.        Molecular weight: 3864.67 Da        Isoelectric Point: 9.0157

>T169414 WP_000170738.1 NZ_CP059917:c4621052-4620945 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASLIVNWLNKRK

Download         Length: 108 bp

>T169414 NZ_CP076470:3654711-3654962 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 67 bp

>AT169414 NZ_CP059917:4621101-4621167 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829L523


Antitoxin

Download structure file

References